Role of Different Molecular Pathways in the Development of Diabetes-Induced Nephropathy

被引:4
作者
Sharma, Virvikram [1 ]
Sharma, P. L. [1 ]
机构
[1] ISF Coll Pharm, Dept Pharmacol, B-1 665-19d,New Kundan Puri,Civil Lines, Ludhiana 141001, Punjab, India
关键词
Diabetes; Nephropathy; Polyol pathway; PKC pathway; Oxidative stress;
D O I
10.4172/2156-6156.S9-004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetes mellitus is heterogeneous primary disorder of carbohydrate metabolism with multiple etiologic factors that generally involves absolute or relative insulin deficiency or insulin resistance or both, which results in hyperglycemia. According to WHO projection; it will be the single largest non-communicable disease worldwide by the year 2025 with the largest diabetic population in India. India leads the world with largest diabetic population thus, being termed the "Diabetes Capital of the World''. However, the prevalence of diabetes is consistently increasing, but still an effective treatment is lacking for the management of this epidemic. The uncontrolled and chronic diabetes mellitus often leads to cardiomyopathy, macrovascular complications and microvascular complications that include retinopathy, neuropathy and nephropathy. Diabetic Nephropathy (DN) is mainly characterized by decreased Glomerular Filteration Rate (GFR), excessive deposition of extracellular matrix proteins, thickening of the peripheral glomerular basement membrane, glomerular hypertrophy, tubulointerstitial fibrosis, increased excretion of albumin and decreased creatinine clearance. Formation of Advanced Glycation End-Products (AGEs), activation of Protein Kinase C (PKC), c-Jun N-terminal kinase (JNK), Mitogen Activated Protein Kinases (MAPKs), oxidative stress are the possible molecular mechanisms of DN. Despite many molecular mechanisms, the pathophysiology of DN is not clearly understood and its management is unsatisfactory.
引用
收藏
页数:7
相关论文
共 50 条
[41]   Important role of long non-coding RNA UBE2R2-AS1 in diabetes-induced renal injury [J].
Chen, Chuanqi ;
Yan, Yanqiong ;
Luo, Qianjun ;
Li, Sufen .
ARCHIVES OF MEDICAL SCIENCE, 2025, 21 (02) :617-629
[42]   Simvastatin alleviates diabetes-induced VEGF-mediated nephropathy via the modulation of Ras signaling pathway [J].
Ho, Cheng ;
Hsu, Yen-Chen ;
Tseng, Ching-Cheng ;
Wang, Feng-Sheng ;
Lin, Chun Liang ;
Wang, Jeng Yi .
RENAL FAILURE, 2008, 30 (05) :557-565
[43]   Diabetes-induced mechanophysiological changes in the esophagus [J].
Zhao, Jingbo ;
Gregersen, Hans .
13TH OESO WORLD CONFERENCE: THE ESOPHAGIOME I, 2016, 1380 :139-154
[44]   Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function [J].
Li, Zhuo ;
Guo, Hua ;
Li, Jia ;
Ma, Tianjiao ;
Zhou, Shanshan ;
Zhang, Zhiguo ;
Miao, Lining ;
Cai, Lu .
CLINICAL SCIENCE, 2020, 134 (18) :2469-2487
[45]   Glutathione status in diabetes-induced embryopathies [J].
Menegola, E ;
Broccia, ML ;
Prati, M ;
Ricolfi, R ;
Giavini, E .
BIOLOGY OF THE NEONATE, 1996, 69 (05) :293-297
[46]   The role of cellular senescence in diabetes mellitus and osteoporosis: molecular pathways and potential interventions [J].
Giovos, Georgios ;
Yavropoulou, Maria P. ;
Yovos, John G. .
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2019, 18 (04) :339-351
[47]   Role of Mitochondrial Stress Protein HSP60 in Diabetes-Induced Neuroinflammation [J].
Liyanagamage, Donisha Shani Niharika Keembiya ;
Martinus, Ryan D. .
MEDIATORS OF INFLAMMATION, 2020, 2020
[48]   The essential role of protein kinase Cδ in diabetes-induced neural tube defects [J].
Cao, Yuanning ;
Zhao, Zhiyong ;
Eckert, Richard L. ;
Reece, E. Albert .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2012, 25 (10) :2020-2024
[49]   Diabetes-induced male infertility: potential mechanisms and treatment options [J].
Huang, Runchun ;
Chen, Jiawang ;
Guo, Buyu ;
Jiang, Chenjun ;
Sun, Weiming .
MOLECULAR MEDICINE, 2024, 30 (01)
[50]   Diabetes-induced metabolic abnormalities in myocardium: Effect of antioxidant therapy [J].
Kowluru, RA ;
Engerman, RL ;
Kern, TS .
FREE RADICAL RESEARCH, 2000, 32 (01) :67-74