RELEASE OF TRYPTASE FROM HUMAN SKIN MAST-CELLS

被引：0
作者：
AMON, EU
机构：
来源：
ALLERGOLOGIE | 1992年 / 15卷 / 11期
关键词：
SKIN MAST CELLS; TRYPTASE; HISTAMINE; PROSTAGLANDIN-D2; IGE;
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Human skin mast cells are involved in the pathogenesis of allergic/pseudoallergic reactions and different inflammatory skin diseases. Their granules contain histamine, chemotactic factors, cytokines and neutral proteases. Among the latter tryptase is an important mediator with effects on coagulation, connective tissue metabolism and the complement system. The present study demonstrates that tryptase is released from isolated human skin mast cells after stimulation with either anti-IgE or the calcium ionophore A23187. We suggest that skin mast cells might be a potent source for tryptase since it is known that tryptase plasma levels are elevated after allergic/pseudoallergic reactions.
引用
收藏
页码：389 / 392
页数：4
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