PHARMACOLOGICAL PROPERTIES OF THE HOMOMERIC ALPHA-7 RECEPTOR

被引：110

作者：

BERTRAND, D ^{[1
]}

BERTRAND, S ^{[1
]}

BALLIVET, M ^{[1
]}

机构：

[1] DEPT BIOCHEM,GENEVA,SWITZERLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 146卷 / 01期

关键词：

NEURONAL; NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA-BUNGAROTOXIN; PHARMACOLOGY; ELECTROPHYSIOLOGY; XENOPUS OOCYTE;

D O I：

10.1016/0304-3940(92)90179-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The pharmacological properties of the alpha-bungarotoxin sensitive alpha7 neuronal nicotinic acetylcholine receptor (nAChR) were studied upon reconstitution in Xenopus oocytes. Channels formed by alpha7 are about 10-fold more sensitive to nicotine and cytisine than to ACh but are little, if at all, activated by the ganglionic agonist 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). Tubocurarine (TC) was found to act as a non-competitive inhibitor, whereas dihydro-beta-erythroidine (DHbetaE) behaves as a pure competitive inhibitor whose blockade is fast and fully reversible. In addition, the alpha7 receptor displays a poor sensitivity to methonium salts. The pharmacological properties of the alpha7 channels are readily distinguishable from those of other identified neuronal nicotinic receptors.

引用

页码：87 / 90

页数：4

共 21 条

[1] DECAMETHONIUM BOTH OPENS AND BLOCKS ENDPLATE CHANNELS [J].