OLD MICROBES WITH NEW FACES - MOLECULAR-BIOLOGY AND THE DESIGN OF NEW VACCINES

被引：11
作者：
CONNELL, N [1 ]
STOVER, CK [1 ]
JACOBS, WR [1 ]
机构：
[1] MEDIMMUNE INC, GAITHERSBURG, MD USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(06)80036-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rational approaches to the design of live attenuated bacterial and viral recombinant vaccine strains are leading to the manipulation of old vaccines and the generation of new ones. The two basic problems to be solved are attenuation of pathogenic strains, and the stable expression of foreign antigens.
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页码：442 / 448
页数：7
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