INFLUENCE OF SIMULTANEOUS SUPPLEMENTATION OF ZINC AND COPPER DURING CHELATION OF LEAD IN RATS

被引：18
作者：
FLORA, SJS
机构：
[1] Division of Pharmacology and Toxicology, Defence Research & Development Establishment
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 1991年 / 10卷 / 05期
关键词：
D O I：
10.1177/096032719101000506
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The influence of zinc and copper supplementation during chelation therapy to reduce zinc and copper imbalance and promote lead elimination from the body, was investigated in rats poisoned with lead. The simultaneous supplementation of zinc and copper increased urinary lead excretion by calcium disodium ethylenediamine tetraacetic acid (CaNa2EDTA) compared to treatment with CaNa2EDTA alone. Combination therapy was effective in potentiating the depletion of blood and renal lead by CaNa2EDTA and meso 2,3-dimercapto succinic acid (DMSA). Combination therapy was also more effective in reducing hepatic lead by CaNa2EDTA and blood lead by 2,3-dimercapto propane sulphonate (DMPS). Zinc and copper supplementation produced a more effective reversal of inhibited blood-delta-aminolevulinic acid dehydratase (ALAD) activity, urinary-delta-aminolevulinic acid excretion and depleted body zinc and copper status.
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页码：331 / 336
页数：6
相关论文
共 33 条
[1]  
APOSHIAN HV, 1990, ANNU REV PHARMACOL, V30, P279
[2]  
ARONSON AL, 1964, J PHARMACOL EXP THER, V146, P241
[3]  
BASINGER MA, 1980, RES COMMUN CHEM PATH, V30, P133
[4]  
BERLIN A, 1974, Z KLIN CHEM KLIN BIO, V12, P389
[5]   CALCIUM EDTA TOXICITY - RENAL EXCRETION OF ENDOGENOUS TRACE-METALS AND THE EFFECT OF REPLETION ON COLLAGEN DEGRADATION IN THE RAT [J].
BRAIDE, VB .
GENERAL PHARMACOLOGY, 1984, 15 (01) :37-41
[6]   COMPARATIVE EFFECTS OF CA-ETHYLENEDIAMINETETRAACETIC ACID (EDTA), ZNEDTA, AND ZNCAEDTA IN MOBILIZING LEAD [J].
BROWNIE, CF ;
ARONSON, AL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 75 (02) :167-172
[7]   TERATOGENIC EFFECT OF CALCIUM EDETATE (CAEDTA) IN RATS AND THE PROTECTIVE EFFECT OF ZINC [J].
BROWNIE, CF ;
BROWNIE, C ;
NODEN, D ;
KROOK, L ;
HALUSKA, M ;
ARONSON, AL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1986, 82 (03) :426-443
[8]   THE EFFECT OF CHELATING-AGENTS ON THE EXCRETION OF ENDOGENOUS METALS [J].
CANTILENA, LR ;
KLAASSEN, CD .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 63 (03) :344-350
[9]  
CORYSLECHTA DA, 1988, J PHARMACOL EXP THER, V246, P84
[10]   URINARY DELTA-AMINOLEVULINIC ACID (ALA) LEVELS IN LEAD POISONING .2. CORRELATION OF ALA VALUES WITH CLINICAL FINDINGS IN 250 CHILDREN WITH SUSPECTED LEAD INGESTION [J].
DAVIS, JR ;
ABRAHAMS, RH ;
FISHBEIN, WI ;
FABREGA, EA .
ARCHIVES OF ENVIRONMENTAL HEALTH, 1968, 17 (02) :164-+
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