DIFFERENCE BETWEEN C3H MICE AND WISTAR RATS IN THE EFFECT OF EXTERNAL GAMMA-IRRADIATION ON FE-59 RELEASE FROM ALVEOLAR MACROPHAGE-INGESTED FE-59 IRON HYDROXIDE COLLOID

被引：1
作者：
TAKAHASHI, S
KUBOTA, Y
SATO, H
机构：
[1] National Institute of Radiological Sciences, Chiba 260, Anagawa 4-9-1, Chiba-shi
来源：
JOURNAL OF RADIATION RESEARCH | 1991年 / 32卷 / 03期
关键词：
FE-59; RELEASE; ALVEOLAR MACROPHAGE; GAMMA-IRRADIATION; MICE AND RATS;
D O I：
10.1269/jrr.32.262
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The effect of external gamma-irradiation on Fe-59 release from alveolar macrophages (AMs) that had ingested Fe-59-iron hydroxide colloid was determined in C3H mice and Wistar rats with an in vitro assay system. The release of Fe-59 from AM was increased by irradiation in mice but not in rats. A significant increase in Fe-59 release was seen in mouse AM cultured for 72 hrs after irradiation at a dose of more than 25 Gy; but, graded doses of gamma-irradiation up to 100 Gy had no effect on Fe-59 release from rat AMs. This difference between mice and rats may be attributable to the magnitude of death of or damage to AM because the survival of AMs assessed by vital staining with crystal violet decreased much more in mice than in rats.
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收藏
页码：262 / 266
页数：5
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