Use of Sofosbuvir/Velpatasvir/Voxilaprevir for Sofosbuvir Nonresponder Genotype 3 HCV Infection in India

被引：4

作者：

Tiwari, Prachi ^{[1
]}

Katiyar, Harshita ^{[1
]}

Rai, Praveer ^{[1
]}

Goel, Amit ^{[1
]}

机构：

[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Gastroenterol, Lucknow 226014, Uttar Pradesh, India

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2022年 / 12卷 / 02期

关键词：

hepatitis c virus; voxilaprevir; velpatasvir; sofosbuvir; resistance associated variant; hepatitis C retreatment; HEPATITIS-C;

D O I：

10.1016/j.jceh.2021.06.023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In India, hepatitis C virus (HCV) infection is treated with sofosbuvir in combination with NS5A inhibitor (Daclatasvir, Ledipasvir, or Velpatasvir). A small proportion of them fail to achieve sustained virological response at 12 weeks (SVR12) and need retreatment. Triple-drug combination (Sofosbuvir/Velpatasvir/Voxilaprevir) is one of the options for retreatment. Here we describe a patient with cirrhosis and genotype 3a infection who was successfully treated with a triple-drug combination after relapse with two courses of Sofosbuvir-containing regimens.

引用

页码：669 / 671

页数：3

共 14 条

[1] Review article: HCV genotype 3 - the new treatment challenge [J].

Ampuero, J. ;

Romero-Gomez, M. ;

Reddy, K. R. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2014, 39 (07) :686-698

[2]

[Anonymous], 2016, VOS SOF VELP VOX TAB

[3] Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection [J].

Bourliere, M. ;

Gordon, S. C. ;

Flamm, S. L. ;

Cooper, C. L. ;

Ramji, A. ;

Tong, M. ;

Ravendhran, N. ;

Vierling, J. M. ;

Tran, T. T. ;

Pianko, S. ;

Bansal, M. B. ;

Ledinghen, V. de ;

Hyland, R. H. ;

Stamm, L. M. ;

Dvory-Sobol, H. ;

Svarovskaia, E. ;

Zhang, J. ;

Huang, K. C. ;

Subramanian, G. M. ;

Brainard, D. M. ;

McHutchison, J. G. ;

Verna, E. C. ;

Buggisch, P. ;

Landis, C. S. ;

Younes, Z. H. ;

Curry, M. P. ;

Strasser, S. I. ;

Schiff, E. R. ;

Reddy, K. R. ;

Manns, M. P. ;

Kowdley, K. V. ;

Zeuzem, S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (22) :2134-2146

[4] Mechanisms of Virologic Failure with Direct-Acting Antivirals in Hepatitis C and Strategies for Retreatment [J].

Costilla, Vanessa ;

Mathur, Neha ;

Gutierrez, Julio A. .

CLINICS IN LIVER DISEASE, 2015, 19 (04) :641-+

[5] Decentralized care with generic direct-acting antivirals in the management of chronic hepatitis C in a public health care setting [J].

Dhiman, Radha K. ;

Grover, Gagandeep S. ;

Premkumar, Madhumita ;

Taneja, Sunil ;

Duseja, Ajay ;

Arora, Sanjeev ;

Rathi, Sahaj ;

Satsangi, Sandeep ;

Roy, Akash .

JOURNAL OF HEPATOLOGY, 2019, 71 (06) :1076-1085

[6] Resistance analysis and treatment outcomes in hepatitis C virus genotype 3-infected patients within the Italian network VIRONET-C [J].

Di Maio, Velia Chiara ;

Barbaliscia, Silvia ;

Teti, Elisabetta ;

Fiorentino, Gianluca ;

Milana, Martina ;

Paolucci, Stefania ;

Pollicino, Teresa ;

Morsica, Giulia ;

Starace, Mario ;

Bruzzone, Bianca ;

Gennari, William ;

Micheli, Valeria ;

Yu La Rosa, Katia ;

Foroghi, Luca ;

Calvaruso, Vincenza ;

Lenci, Ilaria ;

Polilli, Ennio ;

Babudieri, Sergio ;

Aghemo, Alessio ;

Raimondo, Giovanni ;

Sarmati, Loredana ;

Coppola, Nicola ;

Pasquazzi, Caterina ;

Baldanti, Fausto ;

Parruti, Giustino ;

Perno, Carlo Federico ;

Angelico, Mario ;

Craxi, Antonio ;

Andreoni, Massimo ;

Ceccherini-Silberstein, Francesca .

LIVER INTERNATIONAL, 2021, 41 (08) :1802-1814

[7] Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals [J].

Dietz, Julia ;

Susser, Simone ;

Vermehren, Johannes ;

Peiffer, Kai-Henrik ;

Grammatikos, Georgios ;

Berger, Annemarie ;

Ferenci, Peter ;

Buti, Maria ;

Mullhaupt, Beat ;

Hunyady, Bela ;

Hinrichsen, Holger ;

Mauss, Stefan ;

Petersen, Joerg ;

Buggisch, Peter ;

Felten, Gisela ;

Hueppe, Dietrich ;

Knecht, Gaby ;

Lutz, Thomas ;

Schott, Eckart ;

Berg, Christoph ;

Spengler, Ulrich ;

von Hahn, Thomas ;

Berg, Thomas ;

Zeuzem, Stefan ;

Sarrazin, Christoph .

GASTROENTEROLOGY, 2018, 154 (04) :976-+

[8] Real-world re-treatment outcomes of direct-acting antiviral therapy failure in patients with chronic hepatitis C [J].

Elhence, Anshuman ;

Singh, Achintya ;

Anand, Abhinav ;

Kumar, Ramesh ;

Ashraf, Anzar ;

Kumar, Sonu ;

Pradhan, Dibyabhaba ;

Pathak, Piyush ;

Vaishnav, Manas ;

Rajput, Mahendra Singh ;

Banyal, Vikas ;

Nayak, Baibaswata ;

Shalimar .

JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (08) :4982-4991

[9]

Goel A, 2020, NEPHROL DIAL TRANSPL

[10] Daclatasvir and reduced-dose sofosbuvir: An effective and pangenotypic treatment for hepatitis C in patients with estimated glomerular filtration rate [J].

Goel, Amit ;

Bhadauria, Dharmendra S. ;

Kaul, Anupma ;

Verma, Prashant ;

Mehrotra, Mayank ;

Gupta, Amit ;

Sharma, Raj K. ;

Rai, Praveer ;

Aggarwal, Rakesh .

NEPHROLOGY, 2019, 24 (03) :316-321

← 1 2 →