Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

被引：1

作者：

Goncalves, Itamar Luis ^{[1
]}

Kagami, Luciano Porto ^{[1
]}

das Neves, Gustavo Machado ^{[1
]}

Rockenbach, Liliana ^{[1
]}

Davi, Leonardo ^{[1
]}

Soares, Alceu Felipe ^{[1
]}

Garcia, Solange Cristina ^{[2
]}

Eifler-Lima, Vera Lucia ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Fac Farm, Lab Sintese Organ Med LaSOM, Ave Ipiranga 2752, BR-90610000 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Fac Farm, Lab Toxicol LATOX, Ave Ipiranga 2752, BR-90610000 Porto Alegre, RS, Brazil

来源：

MOLBANK | 2018年 / 04期

关键词：

Biginelli reaction; dihydropyrimidin-2-thiones; synthesis; virtual screening; drug design; LaSOM; 282; ecto-5 '-nucleotidase;

D O I：

10.3390/M1029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/ thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets. Synthesis of ethyl 4-(2-fluorophenyl)-6-methy1-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate was achieved through the Biginelli reaction using a functionalized thiourea. In silico studies demonstrated that the compound title showed good potential for interacting with ecto-5'-nucleotidase, which has been considered as a target in designs for anti-cancer drugs.

引用

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