IMMUNOHISTOCHEMICAL DEMONSTRATION OF NEURON SPECIFIC ENOLASE IN BONE-MARROW INFILTRATED BY NEUROBLASTOMA

被引：10

作者：

CAILLAUD, JM

MARTINEZMADRIGAL, F

HARTMANN, O

CARLU, C

机构：

[1] INST GUSTAVE ROUSSY,DEPT HISTOPATHOL,39 RUE CAMILLE DESMOULINS,F-94805 VILLEJUIF,FRANCE

[2] RHONE POULENC SANTE,DEPT TOXICOL,PARIS,FRANCE

[3] INST GUSTAVE ROUSSY,DEPT PAEDIAT ONCOL,F-94805 VILLEJUIF,FRANCE

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1991年 / 44卷 / 04期

关键词：

D O I：

10.1136/jcp.44.4.309

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's disease and two lymphoblastic lymphomas. Twenty seven (32%) of neuroblastoma bone marrows showed metastases by conventional histological techniques and 33 (39%) after immunohistochemical staining with NSE. Five embryonal rhabdomyosarcomas, five Ewing's sarcomas, and two lymphoblastic lymphomas showed bone marrow metastases. Only one of these cases was reactive for NSE. NSE represents a very sensitive immunomarker for the follow up of neuroblastoma and improves detection of bone marrow invasion by neuroblastoma.

引用

页码：309 / 312

页数：4

共 10 条

[1] NEURON SPECIFIC ENOLASE - AN AID TO THE DIAGNOSIS OF MELANOMA AND NEURO-BLASTOMA [J].