Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

被引：3

作者：

Lee, James ^{[1
]}

Rodriguez, Fausto ^{[1
]}

Ali, Syed Z. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Pathol, Path 406,600 N Wolfe St, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ Hosp, Dept Radiol, Baltimore, MD 21287 USA

来源：

ACTA CYTOLOGICA | 2016年 / 60卷 / 05期

关键词：

Gliosarcoma; Fine-needle aspiration; Cytopathology; Extracranial metastasis; Glioblastoma multiforme;

D O I：

10.1159/000448509

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. The cytologic smears displayed a pleomorphic tumor comprised of spindled and epithelioid malignant cells. This case illustrates the ability of FNA to adequately diagnose a rare malignancy in the appropriate clinico-radiologic setting. (C) 2016 S. Karger AG, Basel

引用

页码：490 / 494

页数：5

共 24 条

[1] Gliosarcoma with multiple extracranial metastases: case report and review of the literature [J].

Beaumont, Thomas L. ;

Kupsky, William J. ;

Barger, Geoffrey R. ;

Sloan, Andrew E. .

JOURNAL OF NEURO-ONCOLOGY, 2007, 83 (01) :39-46

[2] Primary and secondary gliosarcomas: clinical, molecular and survival characteristics [J].

Cachia, David ;

Kamiya-Matsuoka, Carlos ;

Mandel, Jacob J. ;

Olar, Adriana ;

Cykowski, Matthew D. ;

Armstrong, Terri S. ;

Fuller, Gregory N. ;

Gilbert, Mark R. ;

De Groot, John F. .

JOURNAL OF NEURO-ONCOLOGY, 2015, 125 (02) :401-410

[3]

Chivukula Mamatha, 2005, Cytojournal, V2, P9, DOI 10.1186/1742-6413-2-9

[4] Clinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results [J].

Galanis, E ;

Buckner, JC ;

Dinapoli, RP ;

Scheithauer, BW ;

Jenkins, RB ;

Wang, CH ;

O'Fallon, JR ;

Farr, G .

JOURNAL OF NEUROSURGERY, 1998, 89 (03) :425-430

[5]

Gjerdrum LM, 1999, BRAIN PATHOL, V9, P421

[6] Clinical Characteristics and Outcomes for a Modern Series of Primary Gliosarcoma Patients [J].

Han, Seunggu J. ;

Yang, Isaac ;

Ahn, Brian J. ;

Otero, Jose J. ;

Tihan, Tarik ;

McDermott, Michael W. ;

Berger, Mitchel S. ;

Prados, Michael D. ;

Parsa, Andrew T. .

CANCER, 2010, 116 (05) :1358-1366

[7] Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity [J].

Han, Seunggu J. ;

Yang, Isaac ;

Tihan, Tarik ;

Prados, Michael D. ;

Parsa, Andrew T. .

JOURNAL OF NEURO-ONCOLOGY, 2010, 96 (03) :313-320

[8]

Huo Z, 2014, INT J CLIN EXP PATHO, V7, P6323

[9] Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features [J].

Karsy, Michael ;

Gelbman, Marshall ;

Shah, Paarth ;

Balumbu, Odessa ;

Moy, Fred ;

Arslan, Erol .

FOLIA NEUROPATHOLOGICA, 2012, 50 (04) :301-321

[10] Survival benefit of stereotactic radiosurgery for patients with malignant glial neoplasms [J].

Kondziolka, D ;

Flickinger, JC ;

Bissonette, DJ ;

Bozik, M ;

Lunsford, LD .

NEUROSURGERY, 1997, 41 (04) :776-783

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