ROLE OF POLYAMINES IN CYTOKINESIS OF MAMMALIAN-CELLS

被引：69

作者：

SUNKARA, PS ^{[1
]}

RAO, PN ^{[1
]}

NISHIOKA, K ^{[1
]}

BRINKLEY, BR ^{[1
]}

机构：

[1] UNIV TEXAS SYST,MD ANDERSON HOSP & TUMOR INST,CTR CANC,DEPT SURG,HOUSTON,TX 77030

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 119卷 / 01期

关键词：

D O I：

10.1016/0014-4827(79)90335-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhibition of polyamine biosynthesis in mammalian cells with methylglyoxal bis-(guanylhydrazone) and α-methyl ornithine inhibits cytokinesis and induces the formation of binucleate cells. Further, these binucleate cells exhibited a diffused pattern of microfilaments compared with the control cells as evidenced by indirect immunofluorescence using anti-actin antibodies. These effects can be reversed by increasing the intracellular levels of the polyamines. The results of this study suggest that polyamines may have a role in the process of cytokinesis and cell division. © 1979.

引用

页码：63 / 68

页数：6

共 20 条

[1] INTERACTION OF OXIDIZED POLYAMINES WITH DNA .I. EVIDENCE FOR FORMATION OF CROSS-LINKS [J].

BACHRACH, U ;

EILON, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 145 (02) :418-&

[2]

Bachrach U., 1973, FUNCTION NATURALLY O

[3] NITROUS-OXIDE - EFFECTS ON MITOTIC APPARATUS AND CHROMOSOME MOVEMENT IN HELA-CELLS [J].

BRINKLEY, BR ;

RAO, PN .

JOURNAL OF CELL BIOLOGY, 1973, 58 (01) :96-106

[4]

BRINKLEY BR, 1975, P NATL ACAD SCI US, V72, P4987

[5] POLYAMINES AND NUCLEIC ACID METABOLISM IN CHICK EMBRYO [J].

CALDARERA, CM .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1970, 171 (03) :709-+

[6]

Cohen S.S., 1971, INTRO POLYAMINES

[7] INCREASED CELLULAR LEVELS OF SPERMIDINE OR SPERMINE ARE REQUIRED FOR OPTIMAL DNA-SYNTHESIS IN LYMPHOCYTES ACTIVATED BY CONCANAVALIN A [J].

FILLINGAME, RH ;

JORSTAD, CM ;

MORRIS, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :4042-4045

[8] IMMUNOFLUORESCENCE OF MITOTIC SPINDLES BY USING MONOSPECIFIC ANTIBODY AGAINST BOVINE BRAIN TUBULIN [J].

FULLER, GM ;

BRINKLEY, BR ;

BOUGHTER, JM .

SCIENCE, 1975, 187 (4180) :948-950

[9] ACTIN ANTIBODY - SPECIFIC VISUALIZATION OF ACTIN-FILAMENTS IN NON-MUSCLE CELLS [J].

LAZARIDES, E ;

WEBER, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (06) :2268-2272

[10] ALPHA-METHYL ORNITHINE, A POTENT COMPETITIVE INHIBITOR OF ORNITHINE DECARBOXYLASE, BLOCKS PROLIFERATION OF RAT HEPATOMA-CELLS IN CULTURE [J].

MAMONT, PS ;

BOHLEN, P ;

MCCANN, PP ;

BEY, P ;

SCHUBER, F ;

TARDIF, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (05) :1626-1630

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