NOVEL ANTINEMATODAL AND ANTIPARASITIC AGENTS FROM PENICILLIUM-CHARLESII .1. FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY

被引：103

作者：

ONDEYKA, JG

GOEGELMAN, RT

SCHAEFFER, JM

KELEMEN, L

ZITANO, L

机构：

[1] Merck & Co., Inc., Rahway

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 11期

关键词：

D O I：

10.7164/antibiotics.43.1375

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Paraherquamide and six novel analogs were isolated from the fermentation of Penicillium charlesii (ATCC 20841). All seven natural products displayed potent antinematodal activity against Caenorhabditis elegans. None of the novel analogs were more potent than paraherquamide.

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页码：1375 / 1379

页数：5

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