COMPARISON OF THE EFFECTS OF GLUCOCORTICOID AND MINERALOCORTICOID INFUSIONS ON BLOOD-PRESSURE IN SHEEP

被引：43

作者：

WHITWORTH, JA ^{[1
]}

COGHLAN, JP ^{[1
]}

DENTON, DA ^{[1
]}

GRAHAM, WF ^{[1
]}

HUMPHERY, TJ ^{[1
]}

SCOGGINS, BA ^{[1
]}

机构：

[1] UNIV MELBOURNE, HOWARD FLOREY INST EXPTL PHYSIOL & MED, PARKVILLE 3052, VICTORIA, AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 1979年 / 1卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.3109/10641967909068630

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It is generally believed that adrenal steroid hypertension is due to the 'mineralocorticoid' and/or 'glucocorticoid' activities of the steroid(s). The present study examines the blood pressure and metabolic effects of steroid hormone infusion in intact conscious sheep to assess the relative contributions of 'glucocorticoid' and 'mineralocorticoid' activity. Cortisol at 5 mg/h increased mean arterial pressure (MAP) but the effect was small (MAP + 10 mm Hg on day 5). This rate of infusion produces blood cortisol levels appropriate for maximal ACTH stimulation. Cortisol at 20 mg/hr produced hypertension (MAP + 25 mm Hg on day 5, p lt;0.01) but also produced the 'mineralocorticoid' effect of severe hypokalaemia. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：649 / 663

页数：15

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