SYNTHETIC APPROACHES, CHEMICAL MODIFICATION AND BIOLOGICAL ACTIVITY OF NON-CONDENSED 1,3,4-THIADIAZOLE DERIVATIVES

被引：0
作者：
Lelyukh, Maryan [1 ]
Adamchuk, Svitlana [1 ]
Harkov, Stefan [2 ]
Chaban, Ihor [1 ]
Demchuk, Inna [3 ]
Shelepeten, Lesya [1 ]
Chaban, Taras [4 ]
机构：
[1] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Chem FPGE, Pekarska 69, UA-79010 Lvov, Ukraine
[2] Burgas Univ Prof Dr Asen Zlatarov, Dept Pharm, Med Coll, St Stambolov 69 Blvd, Burgas 8000, Bulgaria
[3] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, Pekarska 69, UA-79010 Lvov, Ukraine
[4] Danylo Halytsky Lviv Natl Med Univ, Dept Gen Bioinorgan Phys & Colloidal Chem, Pekarska 69, UA-79010 Lvov, Ukraine
来源：
PHARMACIA | 2018年 / 65卷 / 04期
关键词：
synthesis; 1,3,4-thiadiazoles; chemical modification; biological activity;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The chemical features of 1,3,4-thiadiazoles were described in a numerous reviews focusing on the main approaches to the synthesis and modification. Simultaneously, thiadiazole scaffold was identified as the main structural component of approved drugs and biological agents with antimicrobial, antiviral, antitubercular, anti-inflammatory, anticonvulsant and analgetic activity. The significant biological activity of thiadiazole derivates promotes the scientists to further investigation of this heterocycle as a building block for medicinal chemistry. In this review, we discuss the efforts to identify new promising compounds based on aryl/heteryl substituted non-condensed thiadiazoles highliting the main approaches for the conjugation (hybridization) of heterocycles, derivatization and their pharmacological profile.
引用
收藏
页码：72 / 88
页数：17
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