Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats

被引：21

作者：

Goncalves de Freitas, Andre T. A. ^{[1
]}

Lemonica, Lino ^{[2
]}

De Faveri, Julio ^{[3
]}

Pereira, Sergio ^{[4
]}

Bedoya Henao, Maria D. ^{[5
]}

机构：

[1] Univ Estadual Paulista, UNESP Botucatu, Dept Morphol, Sao Paulo, Brazil

[2] Univ Estadual Paulista, UNESP Botucatu, Dept Anesthesiol, Sao Paulo, Brazil

[3] Univ Estadual Paulista, UNESP Botucatu, Dept Pathol, Sao Paulo, Brazil

[4] Univ Estadual Paulista, UNESP Botucatu, Dept Biol Sci, Sao Paulo, Brazil

[5] Univ Estadual Paulista, UNESP Botucatu, Clin Acupuncture & Homeopathy, Sao Paulo, Brazil

来源：

JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES | 2016年 / 9卷 / 01期

关键词：

acupuncture; analgesia; c-fos protein; pain;

D O I：

10.1016/j.jams.2015.08.002

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Pain behavior and awareness are characterized by heightened alertness and anxiety, which begin to disappear as soon as the curative process starts. The present study aimed to quantify c-fos expression in rat spinal cords and brains after a surgical stimulus and with preoperative or postoperative acupuncture. Animals were randomly divided into preoperative and postoperative groups and were then further divided into control, manual acupuncture (MA), or electroacupuncture (EA) groups. Expression of c-fos was quantified using immunohistochemistry. The collected data were analyzed using the t test at a 5% probability level. Presurgery and postsurgery spinal cord c-fos expressions were similar in all of the treatment groups. In the control rats, c-fos expression was higher before surgery than after surgery, contradicting the expected outcome of acupuncture and preemptive analgesia. After treatment, the expression of c-fos in the brains of the rats in the MA and the EA groups was reduced compared with that of the rats in the control group. These findings suggest that acupuncture used as preemptive analgesia in rats is a useful model for studying its application in human treatment.

引用

页码：16 / 21

页数：6

共 22 条

[1]

[Anonymous], 1992, BRAIN MAPS STRUCTURE

[2] The central serotonergic system mediates the analgesic effect of electroacupuncture on Zusanli (ST36) acupoints [J].

Chang, FC ;

Tsai, HY ;

Yu, MC ;

Yi, PL ;

Lin, JG .

JOURNAL OF BIOMEDICAL SCIENCE, 2004, 11 (02) :179-185

[3]

Chen XH, 1996, J PHARMACOL EXP THER, V277, P654

[4] Diagnosis and treatment of low back pain: A joint clinical practice guideline from the American college of physicians and the American pain society [J].

Chou, Roger ;

Qaseem, Amir ;

Snow, Vincenza ;

Casey, Donald ;

Cross, J. Thomas, Jr. ;

Shekelle, Paul ;

Owens, Douglas K. .

ANNALS OF INTERNAL MEDICINE, 2007, 147 (07) :478-491

[5] Analgesia and c-Fos expression in the periaqueductal gray induced by electroacupuncture at the Zusanli point in rats [J].

de Medeiros, MA ;

Canteras, NS ;

Suchecki, D ;

Mello, LEAM .

BRAIN RESEARCH, 2003, 973 (02) :196-204

[6] Brain substrates activated by electroacupuncture (EA) of different frequencies .2. Role of Fos/Jun proteins in EA-induced transcription of preproenkephalin and preprodynorphin genes [J].

Guo, HF ;

Tian, JH ;

Wang, XM ;

Fang, Y ;

Hou, YP ;

Han, JS .

MOLECULAR BRAIN RESEARCH, 1996, 43 (1-2) :167-173

[7] Brain substrates activated by electroacupuncture of different frequencies .1. Comparative study on the expression of oncogene c-fos and genes coding for three opioid peptides [J].

Guo, HF ;

Tian, JH ;

Wang, XM ;

Fang, Y ;

Hou, YP ;

Han, JS .

MOLECULAR BRAIN RESEARCH, 1996, 43 (1-2) :157-166

[8] INDUCTION OF C-FOS-LIKE PROTEIN IN SPINAL-CORD NEURONS FOLLOWING SENSORY STIMULATION [J].

HUNT, SP ;

PINI, A ;

EVAN, G .

NATURE, 1987, 328 (6131) :632-634

[9] Spinal nerve root electroacupuncture for symptomatic treatment of lumbar spinal canal stenosis unresponsive to standard acupuncture: a prospective case series [J].

Inoue, Motohiro ;

Nakajima, Miwa ;

Hojo, Tatsuya ;

Kitakoji, Hiroshi ;

Itoi, Megumi .

ACUPUNCTURE IN MEDICINE, 2012, 30 (02) :103-108

[10] Components of placebo effect: randomised controlled trial inpatients with irritable bowel syndrome [J].

Kaptchuk, Ted J. ;

Kelley, John M. ;

Conboy, Lisa A. ;

Davis, Roger B. ;

Kerr, Catherine E. ;

Jacobson, Eric E. ;

Kirsch, Irving ;

Schyner, Rosa N. ;

Nam, Bong Hyun ;

Nguyen, Long T. ;

Park, Min ;

Rivers, Andrea L. ;

McManus, Claire ;

Kokkotou, Efi ;

Drossman, Douglas A. ;

Goldman, Peter ;

Lembo, Anthony J. .

BMJ-BRITISH MEDICAL JOURNAL, 2008, 336 (7651) :999-1003

← 1 2 3 →