ONE-POT DEPROTECTION AND COUPLING OF PEPTIDES BY THE FMOC STRATEGY

被引：19

作者：

UEKI, M

NISHIGAKI, N

AOKI, H

TSURUSAKI, T

KATOH, T

机构：

来源：

CHEMISTRY LETTERS | 1993年 / 04期

关键词：

D O I：

10.1246/cl.1993.721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

9-Fluorenylmethyloxycarbonyl (Fmoc) group can be quickly removed with tetrabutylammonium fluoride hydrate (TBAF.xH2O) in the presence of a large excess of phenylmethanethiol or 1-octanethiol. Subsequent oxidation of the thiol with bis(1-methyl-1H-tetrazol-5-yl) disulfide simultaneously inactivated the TBAF and enabled one-pot peptide bond elongation by the Fmoc strategy.

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页码：721 / 724

页数：4

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