CALCIUM-PUMP EXPRESSION IN HUMAN BONE AND SOFT-TISSUE TUMORS

被引：4

作者：

KURODA, M ^{[1
]}

HORIUCHI, H ^{[1
]}

OKA, T ^{[1
]}

ISHIDA, T ^{[1
]}

ONO, A ^{[1
]}

KAWAKITA, M ^{[1
]}

MACHINAMI, R ^{[1
]}

机构：

[1] TOKYO METROPOLITAN INST MED SCI,DEPT PHYSIOL CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1993年 / 423卷 / 03期

关键词：

ENDOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM; CALCIUM ATPASE; BONE AND SOFT TISSUE TUMORS; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/BF01614772

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Ninety-one cases of human bone and soft tissue tumours were studied for calcium pump expression by strepto-avidin-biotin immunohistochemical staining with a monoclonal antibody against sarcoplasmic reticulum calcium-ATPase (mAb6F5). Two out of 5 cases of embryonal rhabdomyosarcoma, 1 out of 5 cases of biphasic synovial sarcoma, 4 of 4 cases of chordoma and all of 3 chondrosarcoma cases were positive for mAb6F5. Although this novel monoclonal antibody can be used as a marker of myogenic tumours, the present positive result for endoplasmic reticulum calcium-ATPase (calcium pump) in other tumours including chordoma, chondrosarcoma and synovial sarcoma indicates a wider immunoreactivity. The findings further suggest that intracellular calcium may play an important role in cell proliferation and/or differentiation.

引用

页码：209 / 213

页数：5

共 23 条

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