IMMUNOLOGICAL AND PSYCHOLOGIC THERAPY FOR PATIENTS WITH CHRONIC FATIGUE SYNDROME - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

被引:134
作者
LLOYD, AR
HICKIE, I
BROCKMAN, A
HICKIE, C
WILSON, A
DWYER, J
WAKEFIELD, D
机构
[1] PRINCE WALES HOSP,DEPT IMMUNOL,DIV MED,SYDNEY,NSW,AUSTRALIA
[2] PRINCE WALES HOSP,DEPT INFECT DIS,DIV MED,SYDNEY,NSW,AUSTRALIA
[3] PRINCE WALES HOSP,MOOD DISORDERS UNIT,SYDNEY,NSW,AUSTRALIA
关键词
D O I
10.1016/0002-9343(93)90183-P
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PuRPOSE: To evaluate the potential benefit of immunologic therapy with dialyzable leukocyte extract and psychologic treatment in the form of cognitive-behavioral therapy (CBT) in patients with chronic fatigue syndrome (CFS). PATIENTS AND METHODS- Immunologic and psychologic treatments were administered to 90 adult patients who fulfilled diagnostic criteria for CFS in a double-blind, randomized, and placebo-controlled study. A four-cell trial design allowed the assessment of benefit from immunologic and psychologic treatment individually or in combination. Outcome was evaluated by measurement of global well-being (visual analogue scales), physical capacity (standardized diaries of daily activities), functional status (Karnofsky performance scale), and psychologic morbidity (Profile of Mood States questionnaire), and cell-mediated immunity was evaluated by peripheral blood T-cell subset analysis and delayed-type hypersensitivity skin testing. RESULTs: Neither dialyzable leukocyte extract nor CBT (alone or in combination) provided greater benefit than the nonspecific treatment regimens. CONCLUSIONS. In this study, patients with CFS did not demonstrate a specific response to immunologic and/or psychologic therapy. The improvement recorded in the group as a whole may reflect both nonspecific treatment effects and a propensity to remission in the natural history of this disorder.
引用
收藏
页码:197 / 203
页数:7
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