NICOTINIC ACETYLCHOLINE-RECEPTOR IN DISSOCIATED RAT NUCLEUS-TRACTUS-SOLITARII NEURONS

被引：17
作者：
UENO, S [1 ]
KAKEHATA, S [1 ]
AKAIKE, N [1 ]
机构：
[1] TOHOKU UNIV,SCH MED,DEPT NEUROPHYSIOL,SENDAI,MIYAGI 980,JAPAN
来源：
NEUROSCIENCE LETTERS | 1993年 / 149卷 / 01期
关键词：
RAT DISSOCIATED NUCLEUS-TRACTUS-SOLITARII NEURON; NICOTINIC ACETYLCHOLINE RECEPTOR; ACETYLCHOLINE; PATCH-CLAMP;
D O I：
10.1016/0304-3940(93)90336-J
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The ACh-activated response of the acutely dissociated neuron from the rat nucleus tractus solitarii (NTS) was investigated using conventional and perforated-patch techniques. In the present preparation, ACh and nicotine evoked inward transient currents in approximately 30% of NTS neurons tested. The ACh-activated inward current reversed the direction near 0 mV and was inhibited by D-tubocurarine in a dose-dependent manner. In contrast, muscarine resulted in no detectable changes in the NTS neurons. Some populations of the NTS had nicotinic but no muscarinic acetylcholine receptors.
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页码：15 / 18
页数：4
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