EFFECTS OF CORE COMPONENTS ON INDOMETHACIN RELEASE FROM FILM-COATED GRANULES

被引：6
作者：
LAAKSO, R
EERIKAINEN, S
机构：
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 67卷 / 01期
关键词：
INDOMETHACIN; FILM-COATED GRANULE; FILLER;
D O I：
10.1016/0378-5173(91)90267-R
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of various water-soluble and water-insoluble fillers on the properties of film-coated indomethacin granules were investigated. The fillers used were glucose, lactose, calcium hydrogen phosphate dihydrate, maize starch and microcrystalline cellulose. Swellable maize starch ruptured the film and enhanced indomethacin release. The release profile of indomethacin from granules prepared using glucose and lactose depended on the water solubility of the fillers. The results suggest that indomethacin release from film-coated granules depends on the properties of the fillers used, in particular their solubility in water and swellability.
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页码：79 / 88
页数：10
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