Adiponectin as a new paradigm for approaching Alzheimer's disease

被引：40
作者：
Song, Juhyun [1 ]
Lee, Jong Eun [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Anat, Seoul, South Korea
[2] Yonsei Univ, Plus Project Med Sci BK21, Coll Med, Seoul, South Korea
来源：
ANATOMY & CELL BIOLOGY | 2013年 / 46卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Adiponectin; Alzheimer's disease; Brain insulin system; Cognitive impairment;
D O I：
10.5115/acb.2013.46.4.229
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Adiponectin is an adipocytokine released by the adipose tissue and has multiple roles in the immune system and in the metabolic syndromes such as cardiovascular disease, Type 2 diabetes, obesity and also in the neurodegenerative disorders including Alzheimer's disease. Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system through various mechanisms. Previous studies demonstrated that adiponectin modulates memory and cognitive impairment and contributes to the deregulated glucose metabolism and mitochondrial dysfunction observed in Alzheimer's disease. Here, we aim to summarize recent studies that suggest the potential correlation between adiponectin and Alzheimer's disease.
引用
收藏
页码：229 / 234
页数：6
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