AGE-DEPENDENT DEFICITS IN RADIAL MAZE PERFORMANCE IN THE RAT - EFFECT OF CHRONIC TREATMENT WITH ACETYL-L-CARNITINE

被引：34

作者：

CAPRIOLI, A

GHIRARDI, O

RAMACCI, MT

ANGELUCCI, L

机构：

[1] SIGMA TAU PHARMACEUT CO,BIOL RES LABS,ROME,ITALY

[2] UNIV ROME LA SAPIENZA,INST PHARMACOL 2,I-00185 ROME,ITALY

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1990年 / 14卷 / 03期

关键词：

8-arm radial maze; acetyl-L-carnitine; aging; spatial learning;

D O I：

10.1016/0278-5846(90)90024-B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. An eight-arm radial maze was the experimental model used to investigate spatial learning in rats of different ages and in old rats treated with Acetyl-L-Carnitine. 2. Extramaze visual cues were minimized in order to study the rat's ability to perform using a strategy. 3. The experimental findings indicated a deterioration of the old rat's ability to learn and solve the radial maze. 4. Long-term treatment (8 months) with Acetyl-L-Carnitine was found to antagonize such a deterioration. © 1990.

引用

页码：359 / 369

页数：11

共 25 条

[1] REDUCED LIPOFUSCIN ACCUMULATION IN SENESCENT RAT-BRAIN BY LONG-TERM ACETYL-L-CARNITINE TREATMENT [J].

AMENTA, F ;

FERRANTE, F ;

LUCREZIOTTI, R ;

RICCI, A ;

RAMACCI, MT .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1989, 9 (02) :147-153

[2]

AMENTA F, 1984, NEUROSCI LETT, V18, pS328

[3] SPATIAL-LEARNING AND MEMORY, MAZE RUNNING STRATEGIES AND CHOLINERGIC MECHANISMS IN 2 INBRED STRAINS OF MICE [J].

AMMASSARITEULE, M ;

CAPRIOLI, A .

BEHAVIOURAL BRAIN RESEARCH, 1985, 17 (01) :9-16

[4]

ANGELUCCI L, 1986, CLIN NEUROPHARMACOL, V9, P104

[5]

ANGELUCCI L, 1988, NATO ASI SERIES H, V22, P57

[6] SPATIAL MEMORY DEFICIT IN SENESCENT RATS [J].

BARNES, CA ;

NADEL, L ;

HONIG, WK .

CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE, 1980, 34 (01) :29-39

[7] PRESERVATION OF ACCURATE SPATIAL MEMORY IN AGED RATS [J].

BEATTY, WW ;

BIERLEY, RA ;

BOYD, JG .

NEUROBIOLOGY OF AGING, 1985, 6 (03) :219-225

[8]

BONAVITA E, 1986, INT J CLIN PHARM TH, V24, P511

[9]

Craik F. I. M., 1977, HDB PSYCHOL AGING

[10]

DAVIS HP, 1983, EXP AGING RES, V9, P211, DOI 10.1080/03610738308258454

← 1 2 3 →