SYNTHESIS OF THIENO- AND FURO-PYRIMIDINETHIONES

被引：26

作者：

MANHAS, MS

RAO, VV

SEETHARA.PA

SUCCARDI, D

PAZDERA, J

机构：

[1] Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 14期

关键词：

D O I：

10.1039/j39690001937

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted thiophens carrying adjacent amino- and cyano-groups have been converted into the corresponding pyrimidinethione derivatives in 30-70% yield by condensation with thioamides. Acylation of the thiophen followed by cyclisation in acidic solution gave the corresponding pyrimidones. The same reactions were used successfully with analogous furan compounds.

引用

页码：1937 / &

共 12 条

[1]

Bogert M.T., 1902, J AM CHEM SOC, V24, P1031

[2]

BURCHENAL JOSEPH H., 1954, ANN NEW YORK ACAD SCI, V60, P359

[3] HETEROCYCLEN AUS CH-ACIDEN NITRILEN .9. UBER DIE REAKTION VON ALPHA-HYDROXY-KETONEN MIT MALODINITRIL [J].