ANALYSIS OF GENETIC DATA FROM THE POLYMERASE CHAIN-REACTION

被引：9

作者：

NAVIDI, W ^{[1
]}

ARNHEIM, N ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

STATISTICAL SCIENCE | 1994年 / 9卷 / 03期

关键词：

POLYMERASE CHAIN REACTION; GENE MAPPING; GENE ORDERING; GENETIC DISEASE DIAGNOSIS;

D O I：

10.1214/ss/1177010379

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

The polymerase chain reaction (PCR) makes possible rapid generation of a very large number of copies of a specific region of DNA. This enables the typing of quantities of DNA as small as a single molecule. PCR has led to the development of laboratory experiments which provide new approaches to many classic problems in genetics, such as estimation of linkage, marker ordering and genetic disease diagnosis. We describe some of these experiments and the statistical techniques that have been used to design them and to analyze the data they produce.

引用

页码：320 / 333

页数：14

共 29 条

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[2] SINGLE-SPERM TYPING - DETERMINATION OF GENETIC-DISTANCE BETWEEN THE G-GAMMA-GLOBIN AND PARATHYROID-HORMONE LOCI BY USING THE POLYMERASE CHAIN-REACTION AND ALLELE-SPECIFIC OLIGOMERS [J].