SR-48692, A NONPEPTIDE NEUROTENSIN RECEPTOR ANTAGONIST, BLOCKS THE CARDIOVASCULAR EFFECTS ELICITED BY NEUROTENSIN IN GUINEA-PIGS

被引：11
|
作者：
NISATO, D [1 ]
GUIRAUDOU, P [1 ]
BARTHELEMY, G [1 ]
GULLY, D [1 ]
LEFUR, G [1 ]
机构：
[1] SANOFI RECH,F-31036 TOULOUSE,FRANCE
来源：
LIFE SCIENCES | 1994年 / 54卷 / 07期
关键词：
D O I：
10.1016/0024-3205(94)00411-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In guinea pigs anaesthetized with sodium pentobarbital, SR 48692, a non peptide neurotensin receptor antagonist blunted the blood pressure increase induced by exogenous neurotensin in a dose dependent manner. Furthermore, in isolated spontaneously beating guinea pig atria, both the tachycardia and inotropic responses induced by neurotensin were potently antagonized. SR 48692 did not show any intrinsic effect in vivo or in vitro.
引用
收藏
页码：PL95 / PL100
页数：6
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