DENERVATION IMPAIRS CUTANEOUS MICROVASCULAR FUNCTION AND BLISTER HEALING IN THE RAT HINDLIMB

被引：37

作者：

CARR, RW ^{[1
]}

DELANEY, CA ^{[1
]}

WESTERMAN, RA ^{[1
]}

ROBERTS, RGD ^{[1
]}

机构：

[1] MONASH UNIV,DEPT PHYSIOL,CLAYTON,VIC 3168,AUSTRALIA

来源：

NEUROREPORT | 1993年 / 4卷 / 05期

关键词：

DENERVATION; NEUROPEPTIDES; BLISTER HEALING; NEUROGENIC INFLAMMATION; AXON REFLEXES; LASER DOPPLER FLOWMETRY; MICROVASCULAR REACTIVITY; IONTOPHORESIS; ACETYLCHOLINE; SODIUM NITROPRUSSIDE;

D O I：

10.1097/00001756-199305000-00001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SKIN sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprusside (SNP) evoked direct dilator responses. Resultant changes in skin microvascular blood flux were measured by laser Doppler flowmetry. Compared with their sham-operated control limbs, denervation reduced inflammatory responses (ACh or TNS) by more than 85% and SNP responses by 28% (p < 0.05). Healing of dry-ice blisters raised on the hindpaw 14d post-denervation was significantly slower to complete healing (42d) than controls (26d) and initial inflammation was attenuated, confirming that innervation is important for inflammation and blister-healing.

引用

页码：467 / 470

页数：4

共 26 条

[1] VASODILATATION AND THE DISCOVERY OF ENDOTHELIUM-DERIVED RELAXING FACTOR [J].