REDUCTION OF THE EFFLUENT VOLUME IN HIGH-OUTPUT ILEOSTOMY PATIENTS BY A SOMATOSTATIN ANALOG, SMS 201-995

被引：22
作者：
KUSUHARA, K [1 ]
KUSUNOKI, M [1 ]
OKAMOTO, T [1 ]
SAKANOUE, Y [1 ]
UTSUNOMIYA, J [1 ]
机构：
[1] HYOGO MED UNIV,DEPT SURG 2,1-1 MUKOGAWA CHO,NISHINOMIYA,HYOGO 663,JAPAN
来源：
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1992年 / 7卷 / 04期
关键词：
D O I：
10.1007/BF00341221
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Twelve ileostomy patients were given subcutaneous SMS 201-995 therapy (100 mug t.d.s. for 5 days) in a randomized placebo-controlled trial. All patients had ileostomies constructed 60 cm proximal to the terminal ileum (proximal ileostomy) following restorative proctocolectomy. SMS 201-995 reduced the daily ileostomy output from 997 +/- 52 g to 736 +/- 28 g, P < 0.05, along with a decrease in daily sodium and chloride excretion (sodium: 92.60 +/- 8.51 to 75.22 +/- 8.64 mEq, chloride: 143.46 +/- 8.54 to 113.60 +/- 15.84 mEq; both P < 0.05). There were no significant changes in the plasma levels of glucagon, C peptide, insulin, renin or aldosterone with SMS 201-995 therapy. Patients developed no severe side effects and reported easier management of the ileostomy and a reduction in thirst. Our results suggest a possible clinical role for SMS 201-995 in the management of proximal ileostomy.
引用
收藏
页码：202 / 205
页数：4
相关论文
共 28 条
  • [21] Molla A.M., Gyr K., Bardhan P.K., Molla A., Effect of intravenous somatostatin on stool output in diarrhea due to Vibrio cholerae, Gastroeterology, 87, pp. 845-847, (1984)
  • [22] Vinik A.I., Tsai S.T., Moattari A.R., Cheung P., Cckhauser P.E., Cho K., Somatostatin analogue (SMS 201-995) in the management of gastroenteropancreatic tumors and diarrhea syndromes, Am J Med, 81, pp. 23-40, (1986)
  • [23] Bloom S.R., Somatostatin and the gut, Gastroenterology, 75, pp. 145-147, (1978)
  • [24] Carter R.F., Bitar K.N., Zfass A.M., Makhlouf G.M., Inhibition of VIP-stimulated intestinal secretion and cyclic AMP production by somatostatin in the rat, Gastroenterology, 74, pp. 726-730, (1978)
  • [25] Dharmasthaphorn K., Sherwin R.S., Dobbins J.W., Somatostatin inhibits fluid secretion in the rat jejunum, Gastroenterology, 78, pp. 1554-1558, (1980)
  • [26] Dharathaphorn K., Binder H.J., Dobbins J.W., Somatostatin stimulates sodium and chloride absorption in the rabbit ileum, Gastroenterology, 78, pp. 1559-1565, (1980)
  • [27] Mulvihill S., Passaro E., Debas H., Yamada T., Severe diarrhea after colonic pseudo-obstruction: treatment with somatostatin, N Engl J Med, 310, (1984)
  • [28] Vora J.P., Owens D.R., Ryder R., Atiea J., Luzio S., Hayes T.M., Effect of somatostatin on renal function, BMJ, 292, pp. 1701-1702, (1986)
123