A SACCHAROMYCES-CEREVISIAE CYCLOPHILIN RESIDENT IN THE ENDOPLASMIC-RETICULUM

被引：35
作者：
FRIGERIO, G
PELHAM, HRB
机构：
[1] Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, Hills Road
来源：
JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 233卷 / 01期
关键词：
CYCLOPHILIN; PROLINE ISOMERASE; SACCHAROMYCES-CEREVISIAE; ER LOCALIZATION; HDEL-PROTEIN;
D O I：
10.1006/jmbi.1993.1497
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclophilins are cyclosporin A sensitive peptidyl-prolyl cis-trans isomerases found in the cytoplasm of a wide range of species from Escherichia coli to man. Cyclophilin homologues are translocated into mitochondria, the endoplasmic reticulum and the bacterial periplasmic space. Here, the nucleotide sequence of a non-essential fifth Saccharomyces cerevisiae cyclophilin homologue encoded by chromosome XII is presented. As expected from its hydrophobic signal sequence and a hydrophilic carboxy terminus ending in the tetrapeptide HDEL, epitope-tagged cyclophilin D was found associated with the endoplasmic reticulum. © 1993 Academic Press Limited.
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页码：183 / 188
页数：6
相关论文
共 42 条
[1]  
BENNETZEN JL, 1982, J BIOL CHEM, V257, P3026
[2]   A YEAST CYCLOPHILIN GENE ESSENTIAL FOR LACTATE METABOLISM AT HIGH-TEMPERATURE [J].
DAVIS, ES ;
BECKER, A ;
HEITMAN, J ;
HALL, MN ;
BRENNAN, MB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (23) :11169-11173
[3]  
FOOR F, 1992, NATURE, V360, P682
[4]   THE NUCLEOTIDE-SEQUENCE OF A 3RD CYCLOPHILIN-HOMOLOGOUS GENE FROM SACCHAROMYCES-CEREVISIAE [J].
FRANCO, L ;
JIMENEZ, A ;
DEMOLDER, J ;
MOLEMANS, F ;
FIERS, W ;
CONTRERAS, R .
YEAST, 1991, 7 (09) :971-979
[5]   PROTEIN FOLDING IN THE CELL [J].
GETHING, MJ ;
SAMBROOK, J .
NATURE, 1992, 355 (6355) :33-45
[6]   COMPLEMENTARY-DNA FOR HUMAN T-CELL CYCLOPHILIN [J].
HAENDLER, B ;
HOFERWARBINEK, R ;
HOFER, E .
EMBO JOURNAL, 1987, 6 (04) :947-950
[7]   YEAST CYCLOPHILIN - ISOLATION AND CHARACTERIZATION OF THE PROTEIN, CDNA AND GENE [J].
HAENDLER, B ;
KELLER, R ;
HIESTAND, PC ;
KOCHER, HP ;
WEGMANN, G ;
MOVVA, NR .
GENE, 1989, 83 (01) :39-46
[8]   GENES THAT ALLOW YEAST-CELLS TO GROW IN THE ABSENCE OF THE HDEL RECEPTOR [J].
HARDWICK, KG ;
BOOTHROYD, JC ;
RUDNER, AD ;
PELHAM, HRB .
EMBO JOURNAL, 1992, 11 (11) :4187-4195
[9]   ERD1, A YEAST GENE REQUIRED FOR THE RETENTION OF LUMINAL ENDOPLASMIC-RETICULUM PROTEINS, AFFECTS GLYCOPROTEIN PROCESSING IN THE GOLGI-APPARATUS [J].
HARDWICK, KG ;
LEWIS, MJ ;
SEMENZA, J ;
DEAN, N ;
PELHAM, HRB .
EMBO JOURNAL, 1990, 9 (03) :623-630
[10]   AN ENDOPLASMIC RETICULUM-SPECIFIC CYCLOPHILIN [J].
HASEL, KW ;
GLASS, JR ;
GODBOUT, M ;
SUTCLIFFE, JG .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (07) :3484-3491
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