PRODUCTIVE INTERACTIONS BETWEEN B AND NATURAL-KILLER-CELLS

被引：0

作者：

MICHAEL, A ^{[1
]}

SHAO, A ^{[1
]}

YUAN, D ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PATHOL,DALLAS,TX 75235

来源：

NATURAL IMMUNITY AND CELL GROWTH REGULATION | 1991年 / 10卷 / 02期

关键词：

NATURAL KILLER CELLS; LYMPHOCYTES-B; ISOTYPE SWITCH; IGG2A; INTERFERON-GAMMA; INTERLEUKIN-4;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this report, we have established that natural killer (NK) cells can increase IgG2a secretion by B lymphocytes as well as alter the distribution of the remaining immunoglobulin isotypes. The effect of NK cells on B cell differentiation is similar to that obtained by the direct addition of recombinant interferon-gamma (IFN-gamma) and, therefore, most likely results from the elaboration of IFN-gamma by NK cells, this is a clear demonstration that NK cells can regulate cell function(s) via a mechanism other than cytotoxicity. In addition, we have shown that the induction of NK cells by B lymphocytes requires close interactions between the two cell types. Further, while only low-density B lymphocytes activated in vivo are effective inducers of NK cells, high-density, resting B cells can be rendered effective by preactivation with either interleukin-4 or anti-mu.

引用

页码：71 / 82

页数：12