GAS CHROMATOGRAPHIC ANALYSIS OF AMINE MIXTURES IN DRUG FORMULATIONS

被引：16

作者：

HISHTA, C

LAUBACK, RG

机构：

[1] Bristol Laboratories, Syracuse, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期

关键词：

Amine mixtures in tablets; syrups—analysis; GLC—analysis; Tribenzylamine—internal standard; amine analysis;

D O I：

10.1002/jps.2600580621

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By employing a derivatization scheme, phenylpropanol‐amine hydrochloride, phenylephrine hydrochloride, phenyltolox‐amine citrate, and chlorpheniramine maleate can be separated by means of a single injection in a suitable flame‐ionization gas‐liquid chromatograph. Formulated mixtures of the same components can be analyzed quantitatively in the same way. Precision at the 95 percent confidence level for the four compounds is 4.4 to 7.9 percent. Accuracy with respect to label claim is good. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：745 / &

共 7 条

[1] SEPARATION AND IDENTIFICATION OF SYMPATHOMIMETIC AMINES BY GAS-LIQUID CHROMATOGRAPHY [J].