Genetics of breast cancer in African populations: a literature review

被引：24

作者：

Abbad, A. ^{[1
,2
]}

Baba, H. ^{[3
,4
]}

Dehbi, H. ^{[5
,6
]}

Elmessaoudi-Idrissi, M. ^{[3
,7
]}

Elyazghi, Z. ^{[8
,9
]}

Abidi, O. ^{[10
]}

Radouani, F. ^{[9
]}

机构：

[1] Univ Hassan II Casablanca, Fac Sci, Lab Ecol & Environm, Casablanca, Morocco

[2] Inst Pasteur Maroc, Virol Med & Lab BSL 3, Casablanca, Morocco

[3] Univ Hassan II Casablanca, Fac Sci Ben Msik, Lab Biol & Sante URAC34, Modelisat Mol & Controle Qualite, Casablanca, Morocco

[4] Inst Pasteur Maroc, Lab Immunovirol, Casablanca, Morocco

[5] Univ Hassan II Casablanca, Fac Med & Pharm Casablanca, Lab Pathol Cellulaires & Mol, Casablanca, Morocco

[6] CHU IBN ROCHD, Lab Genet Med, Casablanca, Morocco

[7] Inst Pasteur Maroc, Lab Hepatites Virales, Unite Virol, Casablanca, Morocco

[8] Mohammed V Univ Rabat, Immunogen & Bioinformat Unit, Genom Ctr Human Pathol, Physiol & Physiopathol Team,Fac Sci, Rabat, Morocco

[9] Inst Pasteur Maroc, Chlamydiae & Mycoplasma Lab, Casablanca, Morocco

[10] Minist Sante, Inst Super Profess Infirmieres & Tech Sante ISPIT, Human Mol Genet & Med Genom Lab, Rabat, Morocco

来源：

GLOBAL HEALTH EPIDEMIOLOGY AND GENOMICS | 2018年 / 3卷

关键词：

Africa; breast cancer; genetics; genetic variability;

D O I：

10.1017/gheg.2018.8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide. The present investigation aims to explore genes panel associated with BC in different African regions, and compare them to those studied worldwide. We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk. Data were provided on mutations and polymorphisms associated with BC without fixing a specific date. Case-only studies and clinical trials were excluded. Our study revealed that the majority of African BC genetic studies remain restricted to the investigation of BRCA1 and BRCA2 genes and differences in their mutations spectrum. Therefore, it is necessary to encourage African researchers to characterize more genes involved in BC using methods generating global information such as next-generation sequencing in order to guide specific and more effective therapeutic strategies for the African community.

引用

页数：12

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