COMPLEX-FORMATION REACTIONS OF DICHLORO(L-METHIONINATO)-PALLADIUM(II) WITH INOSINE AND INOSINE 5'-MONOPHOSPHATE - LABILIZATION INDUCED BY THE S-DONOR CHELATE

被引：27

作者：

PRINSLOO, FF

PIENAAR, JJ

VANELDIK, R

机构：

[1] UNIV ERLANGEN NURNBERG,INST INORGAN CHEM,D-91058 ERLANGEN,GERMANY

[2] UNIV WITTEN HERDECKE,INST INORGAN CHEM,W-5810 WITTEN,GERMANY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1995年 / 22期

关键词：

D O I：

10.1039/dt9950003581

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The kinetics and mechanism of the complex-formation reactions of [Pd(met)Cl-2](-) (met=L-methionine anion) with inosine and inosine 5'-monophosphate were studied in detail as a function of the chloride and nucleophile concentrations. temperature and pressure in weakly acidic aqueous solutions. Two consecutive reaction steps which both depend on the nucleophile concentration were observed. A comparison with rate data for the corresponding ethylenediamine and substituted ethylenediamine complexes reveals the significant lability induced by the S-donor chelate in [Pd(met)Cl-2](-). The reported activation parameters underline the operation of an associative ligand-substitution mechanism under all conditions.

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页码：3581 / 3589

页数：9

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共 51 条

[1] VIBRATIONAL SPECTRA OF CO-ORDINATION COMPOUNDS OF FORMULA TRANS- MX2Y2 .3. LOW-FREQUENCY VIBRATIONS OF GROUP 8 COMPLEXES WHERE X = CL BR AND I AND Y = ME2S ME2SE AND ME2TE [J].

ALLKINS, JR ;

HENDRA, PJ .

JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1967, (08) :1325-&

[2] S,O-CHELATION VERSUS S,N-CHELATION IN THE REACTIONS OF THE CIS-DIAMMINEDIAQUAPLATINUM(II) CATION WITH METHIONINE AND S-METHYLCYSTEINE [J].

APPLETON, TG ;

CONNOR, JW ;

HALL, JR .

INORGANIC CHEMISTRY, 1988, 27 (01) :130-137

[3] KINETICS OF COMPLEXATION OF AQUATED PT-II(DIEN) WITH INOSINE AND 1-METHYLINOSINE AS A FUNCTION OF PH [J].

ARPALAHTI, J ;

LEHIKOINEN, P .

INORGANIC CHEMISTRY, 1990, 29 (14) :2564-2567

[4] COORDINATION OF AQUATED CIS-PLATINUM(II) DIAMINES TO PURINE NUCLEOSIDES - KINETICS OF COMPLEX-FORMATION [J].

ARPALAHTI, J ;

LIPPERT, B .

INORGANIC CHEMISTRY, 1990, 29 (01) :104-110

[5] KINETICS AND MECHANISM OF SOLVENT-EXCHANGE AND ANATION REACTIONS OF STERICALLY HINDERED DIETHYLENETRIAMINE COMPLEXES OF PALLADIUM(II) IN AQUEOUS-SOLUTION [J].

BERGER, J ;

KOTOWSKI, M ;

VANELDIK, R ;

FREY, U ;

HELM, L ;

MERBACH, AE .

INORGANIC CHEMISTRY, 1989, 28 (19) :3759-3765

[6] MULTINUCLEAR NMR-STUDIES AND THE KINETICS OF FORMATION OF PLATINUM(II) - ADENINE-NUCLEOTIDE COMPLEXES [J].

BOSE, RN ;

CORNELIUS, RD ;

VIOLA, RE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (15) :4403-4408

[7] KINETICS AND MECHANISM OF SOME FAST ANATION REACTIONS OF A SERIES OF SUBSTITUTED DIENE COMPLEXES OF PALLADIUM(II) - PH DEPENDENCY IN NEUTRAL AND BASIC AQUEOUS-SOLUTIONS [J].

BREET, ELJ ;

VANELDIK, R ;

KELM, H .

INORGANICA CHIMICA ACTA-ARTICLES AND LETTERS, 1984, 85 (02) :151-154

[8] THE MECHANISM OF COMPLEX-FORMATION REACTIONS OF DIETHYLENETRIAMINEPALLADIUM(II) WITH NUCLEOSIDES - A CASE OF ANATION, AQUATION, AND MANIPULATION [J].

BREET, ELJ ;

VANELDIK, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (06) :408-410

[9] KINETICS AND MECHANISM OF THE FUNDAMENTAL SUBSTITUTION PROCESSES DURING COMPLEX-FORMATION OF THE (DIETHYLENETRIAMINE)PALLADIUM(II) CENTER WITH NUCLEIC BASES, NUCLEOSIDES, AND 5'-NUCLEOTIDES IN AQUEOUS-SOLUTION [J].

BREET, ELJ ;

VANELDIK, R .

INORGANIC CHEMISTRY, 1987, 26 (15) :2517-2524

[10] SYNTHESIS AND CHARACTERIZATION OF [D(APGPGPCPCPT)]2 AND ITS ADDUCT WITH THE ANTICANCER DRUG CIS-DIAMMINEDICHLOROPLATINUM(II) [J].

CARADONNA, JP ;

LIPPARD, SJ .

INORGANIC CHEMISTRY, 1988, 27 (08) :1454-1466

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