ANTAGONISM OF THE SYNAPTIC DEPRESSANT ACTIONS OF L-AP4 IN THE LATERAL PERFORANT PATH BY MAP4

被引:55
作者
BUSHELL, TJ
JANE, DE
TSE, HW
WATKINS, JC
DAVIES, CH
GARTHWAITE, J
COLLINGRIDGE, GL
机构
[1] UNIV BRISTOL,SCH MED SCI,DEPT PHARMACOL,BRISTOL BS8 1TD,AVON,ENGLAND
[2] UNIV EDINBURGH,DEPT PHARMACOL,EDINBURGH EH8 9JZ,MIDLOTHIAN,SCOTLAND
[3] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND
关键词
METABOTROPIC GLUTAMATE RECEPTOR; MGLUR4; L-AP4; SYNAPTIC TRANSMISSION; LATERAL PERFORANT PATH; HIPPOCAMPUS;
D O I
10.1016/0028-3908(95)00012-U
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A new mGluR antagonist, MAP4 (the a-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices.
引用
收藏
页码:239 / 241
页数:3
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