Rapid onset of Stevens-Johnson syndrome and toxic epidermal necrolysis after ingestion of acetaminophen

被引：29

作者：

Kim, Eun-Jin ^{[1
]}

Lim, Hyun ^{[1
]}

Park, So Young ^{[1
]}

Kim, Sujeong ^{[1
]}

Yoon, Sun-Young ^{[1
]}

Bae, Yun-Jeong ^{[1
]}

Kwon, Hyouk-Soo ^{[1
]}

Cho, You Sook ^{[1
]}

Moon, Hee-Bom ^{[1
]}

Kim, Tae-Bum ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med,Div Allergy & Clin Immunol, 88 Olympic Ro 43-Gil, Seoul 138736, South Korea

来源：

ASIA PACIFIC ALLERGY | 2014年 / 4卷 / 01期

关键词：

Stevens-Johnson syndrome; Toxic epidermal necrolysis; Drug; Hypersensitivity; Acetaminophen;

D O I：

10.5415/apallergy.2014.4.1.68

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but life-threatening, severe cutaneous adverse reactions most frequently caused by exposure to drugs. Several reports have associated the use of acetaminophen with the risk of SJS or TEN. A typical interval from the beginning of drug therapy to the onset of an adverse reaction is 1-3 weeks. A 43-year-old woman and a 60-year-old man developed skin lesions within 3 days after administration of acetaminophen for a 3-day period. Rapid identification of the symptoms of SJS and TEN caused by ingestion of acetaminophen enabled prompt withdrawal of the culprit drug. After administration of intravenous immunoglobulin G, both patients recovered fully and were discharged. These two cases of rapidly developed SJS/TEN after ingestion of acetaminophen highlight the possibility that these complications can develop within only a few days following ingestion of over-the-counter medications such as acetaminophen.

引用

页码：68 / 72

页数：5

共 16 条

[1] Drug-induced Stevens-Johnson syndrome (SJS']JS), toxic epidermal necrolysis (TEN), and SJS']JS-TEN overlap: A multicentric retrospective study [J].