DIFFERENTIAL-EFFECTS OF TRANSDERMAL ESTRADIOL AND SEQUENTIAL PROGESTOGENS ON IMPEDANCE TO FLOW WITHIN THE UTERINE ARTERIES OF POSTMENOPAUSAL WOMEN

被引:0
作者
HILLARD, TC [1 ]
CRAYFORD, TB [1 ]
BOURNE, TH [1 ]
COLLINS, WP [1 ]
WHITEHEAD, MI [1 ]
CAMPBELL, S [1 ]
机构
[1] UNIV LONDON KINGS COLL HOSP, SCH MED & DENT, ACAD DEPT OBSTET & GYNAECOL, DENMARK HILL, LONDON SE5 8RX, ENGLAND
关键词
POSTMENOPAUSAL; ESTRADIOL; PROGESTOGEN; TRANSVAGINAL ULTRASOUND; PULSATILITY INDEX; UTERINE ARTERY;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To investigate the relationship between estradiol (E2), progestogen, and impedance to blood flow in the uterine artery. Subjects: Twelve postmenopausal women treated tor two cycles with transdermal E2, 0.05 mg/d, with either norethindrone acetate, 0.7 mg, or medroxyprogesterone acetate, 10 mg added sequentially. Measurements: Transvaginal ultrasonography and color flow imaging were used to measure the pulsatility index in the uterine arteries before and during the E2-only and combined E2/progestogen phases. Results: The mean pulsatility index fell to 53% of its pretreatment value within 12 days of E2 administration (P less-than-or-equal-to 0.0001) and was 66% of its pretreatment value in the combined phase (P < 0.005). Similar changes were seen in cycle 2. Time since menopause was correlated with the pretreatment pulsatility index (r = 0.674, P < 0.05) and change in pulsatility index on treatment (r = 0.856, P < 0.001). Conclusion: Gonadal hormones have a profound effect on arterial tone in postmenopausal women; this action may help explain some of the beneficial effects of estrogen on arterial disease risk.
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页码:959 / 963
页数:5
相关论文
共 24 条
  • [1] UTERINE BLOOD-FLOW AND ITS DISTRIBUTION AFTER CHRONIC ESTROGEN AND PROGESTERONE ADMINISTRATION
    ANDERSON, SG
    HACKSHAW, BT
    STILL, JG
    GREISS, FC
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1977, 127 (02) : 138 - 142
  • [2] ESTROGENS, ARTERIAL STATUS, AND POSTMENOPAUSAL WOMEN
    BOURNE, T
    HILLARD, TC
    WHITEHEAD, MI
    CROOK, D
    CAMPBELL, S
    [J]. LANCET, 1990, 335 (8703) : 1470 - 1471
  • [3] BOURNE TH, 1991, GYNECOL ONCOL, V40, P253
  • [4] CARDIOVASCULAR MORTALITY AND NONCONTRACEPTIVE USE OF ESTROGEN IN WOMEN - RESULTS FROM THE LIPID RESEARCH CLINICS PROGRAM FOLLOW-UP-STUDY
    BUSH, TL
    BARRETTCONNOR, E
    COWAN, LD
    CRIQUI, MH
    WALLACE, RB
    SUCHINDRAN, CM
    TYROLER, HA
    RIFKIND, BM
    [J]. CIRCULATION, 1987, 75 (06) : 1102 - 1109
  • [5] CAMPBELL S, 1986, OBSTET GYNECOL, V68, P649
  • [6] THE TRIGLYCERIDE ISSUE - A VIEW FROM FRAMINGHAM
    CASTELLI, WP
    [J]. AMERICAN HEART JOURNAL, 1986, 112 (02) : 432 - 437
  • [7] COMPARISON OF TRANSDERMAL AND ORAL ESTROGEN-PROGESTIN REPLACEMENT THERAPY - EFFECTS ON SERUM-LIPIDS AND LIPOPROTEINS
    CROOK, D
    CUST, MP
    GANGAR, KF
    WORTHINGTON, M
    HILLARD, TC
    STEVENSON, JC
    WHITEHEAD, MI
    WYNN, V
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (03) : 950 - 955
  • [8] DEZIEGLER D, 1991, FERTIL STERIL, V55, P775
  • [9] FALKEBORN M, 1992, IN PRESS BR J OBSTET
  • [10] LIPOPROTEIN (A) CONCENTRATIONS IN POSTMENOPAUSAL WOMEN TAKING NORETHISTERONE
    FARISH, E
    ROLTON, HA
    BARNES, JF
    HART, DM
    [J]. BRITISH MEDICAL JOURNAL, 1991, 303 (6804) : 694 - 694