TRANSCRIPTIONAL REGULATION OF THE IL-2 GENE

被引：501
作者：
JAIN, J [1 ]
LOH, C [1 ]
RAO, A [1 ]
机构：
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115
来源：
CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 03期
关键词：
D O I：
10.1016/0952-7915(95)80107-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The past two years have seen significant advances in our understanding of IL-2 gene transcription. Many of the relevant transcription factors have been identified, the intracellular mechanisms regulating their functions are being elucidated, and the multiple roles oi calcineurin are beginning to be appreciated.
引用
收藏
页码：333 / 342
页数：10
相关论文
共 112 条
  • [61] MCCAFFREY PG, 1993, J BIOL CHEM, V268, P3747
  • [62] MCCAFFREY PG, 1994, J BIOL CHEM, V269, P30445
  • [63] CYCLOSPORINE-A SENSITIVITY OF THE NF-KAPPA-B SITE OF THE IL2R-ALPHA PROMOTER IN UNTRANSFORMED MURINE T-CELLS
    MCCAFFREY, PG
    KIM, PK
    VALGEARCHER, VE
    SEN, R
    RAO, A
    [J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (11) : 2134 - 2142
  • [64] THE LATCH REGION OF CALCINEURIN-B IS INVOLVED IN BOTH IMMUNOSUPPRESSANT-IMMUNOPHILIN COMPLEX DOCKING AND PHOSPHATASE ACTIVATION
    MILAN, D
    GRIFFITH, J
    SU, M
    PRICE, ER
    MCKEON, F
    [J]. CELL, 1994, 79 (03) : 437 - 447
  • [65] STRUCTURE OF THE NF-KAPPA-B P50 HOMODIMER BOUND TO DNA
    MULLER, CW
    REY, FA
    SODEOKA, M
    VERDINE, GL
    HARRISON, SC
    [J]. NATURE, 1995, 373 (6512) : 311 - 317
  • [66] CYCLOSPORINE-A INHIBITS GROWTH OF AUTOCRINE TUMOR-CELL LINES BY DESTABILIZING INTERLEUKIN-3 MESSENGER-RNA
    NAIR, APK
    HAHN, S
    BANHOLZER, R
    HIRSCH, HH
    MORONI, C
    [J]. NATURE, 1994, 369 (6477) : 239 - 242
  • [67] ACTIVATION OF NF-KAPPA-B IN-VIVO IS REGULATED BY MULTIPLE PHOSPHORYLATIONS
    NAUMANN, M
    SCHEIDEREIT, C
    [J]. EMBO JOURNAL, 1994, 13 (19) : 4597 - 4607
  • [68] NEL AE, 1994, J IMMUNOL, V152, P4347
  • [69] INTERLEUKIN-2 TRANSCRIPTIONAL BLOCK BY MULTIFUNCTIONAL CA2+/CALMODULIN KINASE
    NGHIEM, P
    OLLICK, T
    GARDNER, P
    SCHULMAN, H
    [J]. NATURE, 1994, 371 (6495) : 347 - 350
  • [70] NF-AT-AP-1 AND REL-BZIP - HYBRID VIGOR AND BINDING UNDER THE INFLUENCE
    NOLAN, GP
    [J]. CELL, 1994, 77 (06) : 795 - 798
234567891011