TRANSCRIPTIONAL REGULATION OF THE IL-2 GENE

被引:501
作者
JAIN, J [1 ]
LOH, C [1 ]
RAO, A [1 ]
机构
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115
关键词
D O I
10.1016/0952-7915(95)80107-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The past two years have seen significant advances in our understanding of IL-2 gene transcription. Many of the relevant transcription factors have been identified, the intracellular mechanisms regulating their functions are being elucidated, and the multiple roles oi calcineurin are beginning to be appreciated.
引用
收藏
页码:333 / 342
页数:10
相关论文
共 112 条
[1]   DIFFERENTIAL EXPRESSION OF 4 MEMBERS OF THE POU FAMILY OF PROTEINS IN ACTIVATED AND PHORBOL 12-MYRISTATE 13-ACETATE-TREATED JURKAT T-CELLS [J].
BHARGAVA, AK ;
LI, Z ;
WEISSMAN, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10260-10264
[2]   CYCLOSPORINE-A AND FK506 - MOLECULAR MECHANISMS OF IMMUNOSUPPRESSION AND PROBES FOR TRANSPLANTATION BIOLOGY [J].
BIERER, BE ;
HOLLANDER, G ;
FRUMAN, D ;
BURAKOFF, SJ .
CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (05) :763-773
[3]   AN INDUCIBLE CYTOPLASMIC FACTOR (AU-B) BINDS SELECTIVELY TO AUUUA MULTIMERS IN THE 3' UNTRANSLATED REGION OF LYMPHOKINE MESSENGER-RNA [J].
BOHJANEN, PR ;
PETRYNIAK, B ;
JUNE, CH ;
THOMPSON, CB ;
LINDSTEN, T .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (06) :3288-3295
[4]   THE NFAT-1 DNA-BINDING COMPLEX IN ACTIVATED T-CELLS CONTAINS FRA-1 AND JUNB [J].
BOISE, LH ;
PETRYNIAK, B ;
MAO, XH ;
JUNE, CH ;
WANG, CY ;
LINDSTEN, T ;
BRAVO, R ;
KOVARY, K ;
LEIDEN, JM ;
THOMPSSON, CB .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1911-1919
[5]   IDENTIFICATION OF THE IMMUNOPHILINS CAPABLE OF MEDIATING INHIBITION OF SIGNAL-TRANSDUCTION BY CYCLOSPORINE-A AND FK506 - ROLES OF CALCINEURIN BINDING AND CELLULAR LOCATION [J].
BRAM, RJ ;
HUNG, DT ;
MARTIN, PK ;
SCHREIBER, SL ;
CRABTREE, GR .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :4760-4769
[6]   IL-2 PROMOTER-DRIVEN LACZ EXPRESSION AS A MONITORING TOOL FOR IL-2 EXPRESSION IN PRIMARY T-CELLS OF TRANSGENIC MICE [J].
BROMBACHER, F ;
SCHAFER, T ;
WEISSENSTEIN, U ;
TSCHOPP, C ;
ANDERSEN, E ;
BURKI, K ;
BAUMANN, G .
INTERNATIONAL IMMUNOLOGY, 1994, 6 (02) :189-197
[7]  
BRORSON KA, 1991, J IMMUNOL, V147, P3601
[8]   CENTRAL OF I-KAPPA-B-ALPHA PROTEOLYSIS BY SITE-SPECIFIC, SIGNAL-INDUCED PHOSPHORYLATION [J].
BROWN, K ;
GERSTBERGER, S ;
CARLSON, L ;
FRANZOSO, G ;
SIEBENLIST, U .
SCIENCE, 1995, 267 (5203) :1485-1488
[9]   IN-VIVO FOOTPRINTING OF THE HUMAN IL-2 GENE REVEALS A NUCLEAR FACTOR BOUND TO THE TRANSCRIPTION START SITE IN T-CELLS [J].
BRUNVAND, MW ;
KRUMM, A ;
GROUDINE, M .
NUCLEIC ACIDS RESEARCH, 1993, 21 (20) :4824-4829
[10]   EFFECT OF CD28 SIGNAL-TRANSDUCTION ON C-REL IN HUMAN PERIPHERAL-BLOOD T-CELLS [J].
BRYAN, RG ;
LI, YG ;
LAI, JH ;
VAN, M ;
RICE, NR ;
RICH, RR ;
TAN, TH .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :7933-7942