CONTRIBUTION OF TUMOR NECROSIS FACTOR-A TO PULMONARY CYTOKINE EXPRESSION AND LUNG INJURY AFTER HEMORRHAGE AND RESUSCITATION

被引:50
作者
ABRAHAM, E
JESMOK, G
TUDER, R
ALLBEE, J
CHANG, YH
机构
[1] UNIV CALIF LOS ANGELES,MED CTR,DEPT MED,LOS ANGELES,CA 90024
[2] MILES PHARMACEUT,W HAVEN,CT
关键词
CYTOKINES; ACUTE LUNG INJURY; HEMORRHAGE; TUMOR NECROSIS FACTOR-ALPHA; MONOCLONAL ANTIBODIES; CRITICAL ILLNESS; PULMONARY EMERGENCIES; RESUSCITATION;
D O I
10.1097/00003246-199508000-00004
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: To examine the role of tumor necrosis factor-alpha (TNF-alpha) in producing acute inflammatory lung injury after hemorrhage and resuscitation. Design: Prospective, controlled animal study. Setting: Research laboratory. Subjects: Male BALB/c mice. Interventions: Treatment with rat anti-mouse monoclonal anti-TNF-alpha antibodies or control rat immunoglobulin G 1 hr after 30% blood volume hemorrhage and resuscitation. Measurements and Main Results: Therapy with monoclonal anti-TNF-alpha antibodies prevented the posthemorrhage increases in pulmonary TNF-alpha and interferon-gamma protein levels that normally occur after blood loss, Administration of monoclonal anti-TNF-alpha antibodies also diminished the increases in interleukin-1 beta interleukin-6, and interleukin-10 mRNA, but not the increases in TNF-alpha and interferon-gamma mRNA, which are found in the lungs following hemorrhage. In addition, therapy with monoclonal anti-TNF-alpha antibodies was associated with significant improvement in the histologic parameters of posthemorrhage lung injury, particularly intra-alveolar hemorrhage and pulmonary vascular congestion. Conclusions: These results indicate that TNF-alpha has an important role in the development of acute inflammatory lung injury after blood loss, Blockade of TNF-alpha with monoclonal antibodies significantly reduces hemorrhage-induced lung injury.
引用
收藏
页码:1319 / 1326
页数:8
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