SIMULTANEOUS OSCILLATIONS IN THE MEMBRANE-POTENTIAL OF PIG CORONARY-ARTERY ENDOTHELIAL AND SMOOTH-MUSCLE CELLS

被引:73
|
作者
VONDERWEID, PY
BENY, JL
机构
[1] Department of Zoology and Animal Biology, University of Geneva
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1993年 / 471卷
关键词
D O I
10.1113/jphysiol.1993.sp019888
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The effects of tetrabutylammonium (TBA) on the mechanical tension and on the electrical behaviour of endothelial and smooth muscle cells were studied in intact porcine coronary artery strips. 2. Superfusion of strips with TBA (2-20 mM) induced mechanical oscillations, leading to an increase in tonic isometric tension. 3. TBA-induced mechanical oscillations were correlated with fluctuations of the membrane potential of endothelial cells, which were identified by iontophoretic injection of Lucifer Yellow. 4. The endothelial cell membrane potential fluctuations appeared as action potentials or smaller amplitude slow waves, and were synchronized with electrical membrane potential fluctuations of the underlying coronary smooth muscle cells. 5. Oscillations induced by TBA in smooth muscle cells were not affected by removal of the endothelium, and depended on the presence of calcium in the external medium. 6. To our knowledge, this is the first description of action potential-like fluctuations in the endothelium. It is concluded that the oscillations were generated in the smooth muscle and that they propagate to the endothelium. The question of the mode of propagation of the signal is discussed.
引用
收藏
页码:13 / 24
页数:12
相关论文
共 50 条
  • [41] EFFECTS OF CROMAKALIM ON THE CONTRACTION AND THE MEMBRANE-POTENTIAL OF THE CIRCULAR SMOOTH-MUSCLE OF GUINEA-PIG STOMACH
    ITO, K
    KANNO, T
    SUZUKI, K
    MASUZAWAITO, K
    TAKEWAKI, T
    OHASHI, H
    ASANO, M
    SUZUKI, H
    BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (02) : 335 - 340
  • [42] MECHANISMS OF VERAPAMIL AND NOREPINEPHRINE RELAXING EFFECTS ON CORONARY-ARTERY SMOOTH-MUSCLE CELLS
    NIKITINA, EI
    SHUBA, MF
    FIZIOLOGICHESKII ZHURNAL, 1983, 29 (01): : 17 - 22
  • [43] 2 TYPES OF POTASSIUM CURRENT IDENTIFIED IN CORONARY-ARTERY SMOOTH-MUSCLE CELLS
    WAN, X
    LEBLANC, N
    FASEB JOURNAL, 1992, 6 (01): : A251 - A251
  • [44] ELECTRICAL AND MECHANICAL-PROPERTIES OF SMOOTH-MUSCLE CELLS OF HUMAN CORONARY-ARTERY
    INOUE, K
    HASEGAWA, H
    MIYAZAWA, I
    IINO, T
    HOSODA, S
    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1986, 50 (08): : 703 - 704
  • [45] CHARACTERISTICS OF POTENTIAL-DEPENDENT CALCIUM INWARD CURRENT IN THE MEMBRANE OF ISOLATED SMOOTH-MUSCLE CELL OF CORONARY-ARTERY
    GANITKEVICH, VY
    SMIRNOV, SV
    SHUBA, MF
    BIOLOGICHESKIE MEMBRANY, 1989, 6 (01): : 51 - 58
  • [46] INWARD CURRENTS ACTIVATED BY CALCIUM RELEASE IN CORONARY-ARTERY SMOOTH-MUSCLE CELLS
    STUREK, M
    HU, Q
    FASEB JOURNAL, 1993, 7 (04): : A757 - A757
  • [47] SPONTANEOUS OUTWARD CURRENTS IN THE MEMBRANE OF SINGLE ISOLATED SMOOTH-MUSCLE CELL OF CORONARY-ARTERY
    GANITKEVICH, VY
    SHUBA, MF
    BIOLOGICHESKIE MEMBRANY, 1988, 5 (12): : 1312 - 1320
  • [48] RELATIONSHIP BETWEEN MEMBRANE-POTENTIAL AND TENSION IN MYTILUS SMOOTH-MUSCLE
    HIDAKA, T
    GOTO, M
    JOURNAL OF COMPARATIVE PHYSIOLOGY, 1973, 82 (04): : 357 - 364
  • [49] MEMBRANE-POTENTIAL AND EXCITATION-CONTRACTION COUPLING IN SMOOTH-MUSCLE
    CASTEELS, R
    DROOGMANS, G
    FEDERATION PROCEEDINGS, 1982, 41 (12) : 2879 - 2882
  • [50] EFFECT OF TEA ON MEMBRANE-POTENTIAL AND CONTRACTION OF VASCULAR SMOOTH-MUSCLE
    HAEUSLER, G
    EXPERIENTIA, 1974, 30 (06): : 695 - 695