The Role of Immune Cells in Chronic HBV Infection

被引：34
作者：
Li, Hai-Jun [1 ]
Zhai, Nai-Cui [1 ]
Song, Hong-Xiao [1 ]
Yang, Yang [1 ]
Cui, An [1 ]
Li, Tian-Yang [1 ]
Tu, Zheng-Kun [1 ]
机构：
[1] Jilin Univ, Hosp 1, Dept Translat Med, Changchun, Jilin, Peoples R China
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2015年 / 3卷 / 04期
关键词：
Immune cells; Natural killer cells; CD8(+) T cells; Hepatitis B virus;
D O I：
10.14218/JCTH.2015.00026
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Consequently, HBV DNA and viral proteins, like HBV early antigen (HBeAg) and HBV surface antigen (HBsAg), can be easily detected in serum. Chronic infection with HBV is the result of an ineffective antiviral immune response towards the virus. In this review, we discuss the role of immune cells in chronic HBV infection. (C) 2015 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved.
引用
收藏
页码：277 / 283
页数：7
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