The Role of Immune Cells in Chronic HBV Infection

被引：34
作者：
Li, Hai-Jun [1 ]
Zhai, Nai-Cui [1 ]
Song, Hong-Xiao [1 ]
Yang, Yang [1 ]
Cui, An [1 ]
Li, Tian-Yang [1 ]
Tu, Zheng-Kun [1 ]
机构：
[1] Jilin Univ, Hosp 1, Dept Translat Med, Changchun, Jilin, Peoples R China
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2015年 / 3卷 / 04期
关键词：
Immune cells; Natural killer cells; CD8(+) T cells; Hepatitis B virus;
D O I：
10.14218/JCTH.2015.00026
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Consequently, HBV DNA and viral proteins, like HBV early antigen (HBeAg) and HBV surface antigen (HBsAg), can be easily detected in serum. Chronic infection with HBV is the result of an ineffective antiviral immune response towards the virus. In this review, we discuss the role of immune cells in chronic HBV infection. (C) 2015 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved.
引用
收藏
页码：277 / 283
页数：7
相关论文
共 93 条
[1]   Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals [J].
Anthony, D. D. ;
Umbleja, T. ;
Aberg, J. A. ;
Kang, M. ;
Medvik, K. ;
Lederman, M. M. ;
Peters, M. G. ;
Koziel, M. J. ;
Overton, E. T. .
VACCINE, 2011, 29 (19) :3558-3563
[2]   Phenotype and Function of Human T Lymphocyte Subsets: Consensus and Issues [J].
Appay, Victor ;
van Lier, Rene A. W. ;
Sallusto, Federica ;
Roederer, Mario .
CYTOMETRY PART A, 2008, 73A (11) :975-983
[3]   RETRACTED: Elevated T regulatory cells in tolerance in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin (Retracted article see vol 177, pg 2023, 2006) [J].
Asiedu, CK ;
Goodwin, KJ ;
Balgansuren, G ;
Jenkins, SM ;
Le Bas-Bernardet, S ;
Jargal, U ;
Neville, DM ;
Thomas, JM .
JOURNAL OF IMMUNOLOGY, 2005, 175 (12) :8060-8068
[4]   Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells [J].
Auffray, Cedric ;
Sieweke, Michael H. ;
Geissmann, Frederic .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :669-692
[5]   CYTOTOXIC T-LYMPHOCYTE RESPONSE TO A WILD-TYPE HEPATITIS-B VIRUS EPITOPE IN PATIENTS CHRONICALLY INFECTED BY VARIANT VIRUSES CARRYING SUBSTITUTIONS WITHIN THE EPITOPE [J].
BERTOLETTI, A ;
COSTANZO, A ;
CHISARI, FV ;
LEVRERO, M ;
ARTINI, M ;
SETTE, A ;
PENNA, A ;
GIUBERTI, T ;
FIACCADORI, F ;
FERRARI, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) :933-943
[6]   Monocytes from Chronic HBV Patients React In Vitro to HBsAg and TLR by Producing Cytokines Irrespective of Stage of Disease [J].
Boltjes, Arjan ;
Groothuismink, Zwier M. ;
van Oord, Gertine W. ;
Janssen, Harry L. A. ;
Woltman, Andrea M. ;
Boonstra, Andre .
PLOS ONE, 2014, 9 (05)
[7]   Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection [J].
Boni, Carolina ;
Fisicaro, Paola ;
Valdatta, Caterina ;
Amadei, Barbara ;
Di Vincenzo, Paola ;
Giuberti, Tiziana ;
Laccabue, Diletta ;
Zerbini, Alessandro ;
Cavalli, Albertina ;
Missale, Gabriele ;
Bertoletti, Antonio ;
Ferrari, Carlo .
JOURNAL OF VIROLOGY, 2007, 81 (08) :4215-4225
[8]   Immunology of hepatitis B and hepatitis C virus infections [J].
Boonstra, Andre ;
Woltman, Andrea M. ;
Janssen, Harry L. A. .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2008, 22 (06) :1049-1061
[9]   Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis [J].
Cao, D ;
Malmström, V ;
Baecher-Allan, C ;
Hafler, D ;
Klareskog, L ;
Trollmo, C .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) :215-223
[10]   Immune tolerance split between hepatitis B virus precore and core proteins [J].
Chen, M ;
Sällberg, M ;
Hughes, J ;
Jones, J ;
Guidotti, LG ;
Chisari, FV ;
Billaud, JN ;
Milich, DR .
JOURNAL OF VIROLOGY, 2005, 79 (05) :3016-3027
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