GENERATION OF REACTIVE OXYGEN SPECIES BY BLOOD MONOCYTES IN HUMAN PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX INFECTIONS

被引：15

作者：

DUBEY, ML

RAI, SK

GANGULY, NK

KALRA, A

VARMA, SC

MAHAJAN, RC

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT EXPTL MED,CHANDIGARH 160012,INDIA

[2] POSTGRAD INST MED EDUC & RES,DEPT INTERNAL MED,CHANDIGARH 160012,INDIA

来源：

APMIS | 1991年 / 99卷 / 03期

关键词：

REACTIVE OXYGEN SPECIES; BLOOD MONOCYTES; PLASMODIUM-FALCIPARUM; PLASMODIUM-VIVAX;

D O I：

10.1111/j.1699-0463.1991.tb05140.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Generation of reactive oxygen radicals by peripheral blood monocytes was measured by luminol-dependent chemiluminescence in 23 P. vivax- and 7 P. falciparum-infected patients. The chemiluminescence index (CLI) was not found to be significantly higher in P. vivax-infected cases than in healthy controls. But in patients with P. falciparum infection, the CLI was significantly higher compared to controls as well as to P. vivax-infected patients. In two severe and complicated P. falciparum-infected cases, CLI was found to be higher than in mild cases. As immunosuppression is more marked in falciparum malaria than in vivax cases, the role of oxygen radical generation in immunopathology and causation of immunosuppression in falciparum malaria needs further investigation.

引用

收藏

页码：210 / 212

页数：3

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