IMMUNOCHEMICAL STUDIES OF TOBACCO MOSAIC-VIRUS .3. DEMONSTRATION OF 5 ANTIGENIC REGIONS IN THE PROTEIN SUB-UNIT

被引：0
作者：
DELMILTON, RC
VANREGENMORTEL, MHV
机构：
[1] Department of Microbiology, University of Cape Town, Rondebosch
来源：
MOLECULAR IMMUNOLOGY | 1979年 / 16卷 / 03期
关键词：
D O I：
10.1016/0161-5890(79)90143-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antigenic determinants of the protein sub-unit of tobacco mosaic virus have been studied by inhibition of complement fixation experiments. The viral sub-unit has been found to possess five epitopes. Three of them situated in tryptic peptides 1.4 and 8 are cryptotopes, i.e. epitopes absent from the outer surface of the assembled viral capsid. Two other epitopes situated in tryptic peptides 1 and 12 are located in a region that is recognized by both anti-sub-unit and anti-viral antibodies. When the results are analyzed in terms of the three-dimensional structure of the viral sub-unit, it appears that all the antigenic reactive regions occupy highly accessible locations on the surface of the protein. © 1979.
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页码：179 / 184
页数：6
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