NUCLEAR-MAGNETIC-RESONANCE STUDIES OF N-H BONDS IN PLATINUM ANTICANCER COMPLEXES - DETECTION OF REACTION INTERMEDIATES AND HYDROGEN-BONDING IN GUANOSINE 5'-MONOPHOSPHATE ADDUCTS OF CIS-[PTCL2(NH3)2]

被引：39

作者：

BERNERSPRICE, SJ

FRENKIEL, TA

RANFORD, JD

SADLER, PJ

机构：

[1] UNIV LONDON, BIRKBECK COLL,DEPT CHEM, GORDON HOUSE & CHRISTOPHER INGOLD LAB, 29 GORDON SQ, LONDON WC1H 0PP, ENGLAND

[2] GRIFFITH UNIV, DIV SCI & TECHNOL, NATHAN, QLD 4111, AUSTRALIA

[3] NATL INST MED RES, CTR BIOMED, LONDON NW7 1AA, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1992年 / 13期

关键词：

D O I：

10.1039/dt9920002137

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reactions between N-15-labelled cis-[PtCl2(NH3)2] and guanosine 5'-monophosphate (GMP) have been studied in aqueous solutions at millimolar concentrations using N-15-edited one-dimensional H-1 NMR spectroscopy, and two-dimensional H-1,N-15] heteronuclear multiple quantum coherence NMR spectroscopy; the reactive species [PtCl(H2O)(NH3)2]+ was detected, as well as hydrogen bonding in the product [Pt(GMP-N7)2(NH3)2]2+.

引用

页码：2137 / 2139

页数：3

共 24 条

[1] N-15 AND PT-195 NMR-SPECTRA OF PLATINUM AMMINE COMPLEXES - TRANSINFLUENCE AND CIS-INFLUENCE SERIES BASED ON PT-195-N-15 COUPLING-CONSTANTS AND N-15 CHEMICAL-SHIFTS [J].

APPLETON, TG ;

HALL, JR ;

RALPH, SF .

INORGANIC CHEMISTRY, 1985, 24 (26) :4685-4693

[2] PT-195 NMR KINETIC AND MECHANISTIC STUDIES OF CIS-DIAMMINEDICHLOROPLATINUM AND TRANS-DIAMMINEDICHLOROPLATINUM(II) BINDING TO DNA [J].

BANCROFT, DP ;

LEPRE, CA ;

LIPPARD, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (19) :6860-6871

[3] CORRELATION OF PROTON AND N-15 CHEMICAL-SHIFTS BY MULTIPLE QUANTUM NMR [J].

BAX, A ;

GRIFFEY, RH ;

HAWKINS, BL .

JOURNAL OF MAGNETIC RESONANCE, 1983, 55 (02) :301-315

[4] HYDROLYSIS PRODUCTS OF CISPLATIN - PKA DETERMINATIONS VIA [H-1, N-15] NMR-SPECTROSCOPY [J].

BERNERSPRICE, SJ ;

FRENKIEL, TA ;

FREY, U ;

RANFORD, JD ;

SADLER, PJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (10) :789-791

[5] REACTION-PRODUCTS OF CIS-DIAMMINEPLATINUM(II) COMPOUNDS WITH 5'-GUANOSINE MONOPHOSPHATE CHARACTERIZED BY HIGH-FREQUENCY PROTON NMR [J].

DIJT, FJ ;

CANTERS, GW ;

DENHARTOG, JHJ ;

MARCELIS, ATM ;

REEDIJK, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (12) :3644-3647

[6]

Farrell N., 1989, TRANSITION METAL COM

[7] WEAK SATELLITE SIGNALS IN HIGH-RESOLUTION NMR-SPECTRA - SEPARATING THE WHEAT FROM THE CHAFF [J].

FREEMAN, R ;

MARECI, TH ;

MORRIS, GA .

JOURNAL OF MAGNETIC RESONANCE, 1981, 42 (02) :341-345

[8]

HACKER MP, 1984, PLATINUM COORDINATIO

[9] A D(GPG)-PLATINATED DECANUCLEOTIDE DUPLEX IS KINKED - AN EXTENDED NMR AND MOLECULAR MECHANICS STUDY [J].

HERMAN, F ;

KOZELKA, J ;

STOVEN, V ;

GUITTET, E ;

GIRAULT, JP ;

HUYNHDINH, T ;

IGOLEN, J ;

LALLEMAND, JY ;

CHOTTARD, JC .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 194 (01) :119-133

[10]

ISMAIL IM, 1983, ACS SYM SER, V209, P171

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