EFFECT OF 5-HT3 RECEPTOR ANTAGONIST (ONDANSETRON) ON FUNCTIONING HUMAN PANCREATIC CARCINOID CELLS

被引：2

作者：

ISHIZUKA, J

HSIEH, AC

TOWNSEND, CM

THOMPSON, JC

机构：

[1] Department of Surgery, The University of Texas Medical Branch, Galveston

来源：

SURGICAL ONCOLOGY-OXFORD | 1993年 / 2卷 / 04期

关键词：

CA2+; CAMP; CARCINOID CELLS; 5-HYDROXYTRYPTAMINE; ONDANSETRON; PHOSPHATIDYLINOSITOL HYDROLYSIS;

D O I：

10.1016/0960-7404(93)90010-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

5-Hydroxytryptamine (5-HT) is a mitogen for selected cell types. We have reported that 5-HT is an autocrine growth factor for functioning human pancreatic carcinoid (BON) cells; autocrine growth effect is transmitted by 5-HT1A but not 5-HT1C/2 receptors, activation of which decreases cyclic AMP production through a pertussis toxin-sensitive inhibitory GTP-binding protein. In this study, the effect of 5-HT3 receptor antagonist, ondansetron, on BON was examined. Ondansetron did not affect growth of BON cells and also affected neither stimulation of phosphatidylinositol hydrolysis or inhibition of cyclic AMP production evoked by 5-HT in BON cells. Ondansetron, however, inhibited mobilization of intracellular calcium evoked by 5-HT. Present findings suggest that BON cells possess 5-HT3 receptors, but their roles in pancreatic carcinoid cells are still unknown.

引用

页码：221 / 225

页数：5

共 16 条

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