INTRAPERITONEALLY INJECTED CHOLECYSTOKININ-OCTAPEPTIDE ACTIVATES PICA IN RATS

被引：20

作者：

MCCUTCHEON, B

BALLARD, M

MCCAFFREY, RJ

机构：

[1] Department of Psychology, The University at Albany, State University of New York, Albany

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 03期

关键词：

CHOLECYSTOKININ; INGESTION; PICA; RATS; KAOLIN;

D O I：

10.1016/0031-9384(92)90177-4

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Cholecystokinin-octapeptide (CCK-8) was injected intraperitoneally into rats to see if it could cause them to eat kaolin (clay)-a pica behavior which has been shown to indicate gastric distress. In the first study, a single large dose of CCK-8 (20-mu-g/kg) failed to produce pica. In the second study, 4 smaller doses of CCK-8 (8-mu-g/kg), 30 min apart, produced significant ingestion of kaolin compared to the baseline condition of vehicle injections. The pica was comparable to that observed in another group of rats given a toxic dose of LiCl (127 mg/kg. IP). It is concluded that interperitoneal injections of CCK-8 can induce a state of gastric distress in the rat.

引用

页码：543 / 547

页数：5

共 20 条

[1] THE PHYSIOLOGY OF APPETITE [J].