RADIATION-INDUCED GRAFT-COPOLYMERIZATION OF METHACRYLIC-ACID ON TO POLY(VINYL CHLORIDE) FILMS AND THEIR THROMBOGENICITY

被引：18

作者：

SINGH, J

RAY, AR

SINGHAL, JP

SINGH, H

机构：

[1] INDIAN INST TECHNOL,CTR BIOMED ENGN,DELHI HAUZ KHAS,NEW DELHI 110016,INDIA

[2] ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA

来源：

BIOMATERIALS | 1990年 / 11卷 / 07期

关键词：

copolymers; poly(vinyl chloride); Thrombogenesis;

D O I：

10.1016/0142-9612(90)90060-4

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Methacrylic acid (MAA) was radiation grafted on to poly(vinyl chloride) (PVC) films to improve the blood compatibility of PVC. The thromobogenicity of MAA grafted PVC was evaluated by thrombus formation, platelet adhesion and haemolytic activity in vitro. The hydrophilicity of grafted PVC films was investigated by contact angle measurement. Methacrylic acid grafted PVC film showed lower thrombogenicity than that of PVC. It was found that the weight of thrombus formed on grafted PVC was less than that of PVC and glass and decreased with the increase in the graft level. The adhesion of platelets on grafted PVC was retarded after grafting with MAA hydrogels. © 1990.

引用

页码：473 / 476

页数：4

共 25 条

[1]

BAIER RE, 1970, T AM SOC ART INT ORG, V16, P50

[2]

BAJDA A, 1976, Patent No. 98867

[3]

BENDERSKII LL, 1978, PLAST MASSY, V6, P73

[4] INVIVO ANTITHROMBOGENICITY OF POLY(TETRAFLUOROETHYLENE) RADIATION-GRAFT COPOLYMERIZED WITH ACRYLAMIDE [J].