PARTICLE-SIZE OF BECLOMETHASONE DIPROPIONATE PRODUCED BY 2 NEBULIZERS AND 2 SPACING DEVICES

被引：34

作者：

OCALLAGHAN, C

机构：

[1] Department of Child Health, University Hospital

来源：

THORAX | 1990年 / 45卷 / 02期

关键词：

D O I：

10.1136/thx.45.2.109

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

An impactor method was used to assess the amount of beclomethasone dipropionate in particles less than 5 μm produced by two nebulisers (Pari Inhalierboy, Medix Traveller compressor with cirrhus nebuliser chamber) and two spacer devices (Volumatic and Nebuhaler). After nebulisation of 3 ml (150 μg) beclomethasone diproprionate the amount of drug in particles less than 5 μm was 16 μg (GSD 1.1) with the Pari Inhalierboy, and 27 μg (1.4) with the Medix Traveller with cirrhus nebuliser. This was less than the amount in particles less than 5 μm after three metered dose inhaler actuations (150 μg) from the Nebuhaler (58.2 (1) μg) or the Volumatic spacer (46.5 (1)μg). The greater amount of beclomethasone dipropionate in small particles with administration from a metered dose inhaler with a spacer device means that considerably more drug is likely to reach the airways than when the same dose is given by the two nebulisers studied.

引用

页码：109 / 111

页数：3

共 10 条

[1]

Agnew J.E., 1984, AEROSOLS LUNG CLIN E, P49

[2]

BELL JH, 1973, J PHARM PHARM S, V2, P32

[3] NEBULIZED BECLOMETHASONE DIPROPIONATE IN RECURRENT OBSTRUCTIVE EPISODES AFTER ACUTE BRONCHIOLITIS [J].