POTENTIATION OF ANGIOTENSIN-II-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS, CALCIUM MOBILIZATION AND CONTRACTION OF RENAL MESANGIAL CELLS UPON DOWN-REGULATION OF PROTEIN KINASE-C

被引：38
作者：
PFEILSCHIFTER, J
FANDREY, J
OCHSNER, M
WHITEBREAD, S
DEGASPARO, M
机构：
[1] CIBA GEIGY AG,CENT FUNCT RES,CH-4002 BASEL,SWITZERLAND
[2] MED UNIV LUBEK,INST PHYSIOL,W-2400 LUBECK,GERMANY
来源：
FEBS LETTERS | 1990年 / 261卷 / 02期
关键词：
Angiotensin II; Ca[!sup]2+[!/sup; Contraction; Mesangial cell; Phosphoinositide; Protein kinase C;
D O I：
10.1016/0014-5793(90)80578-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long-term pretreatment of rat mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulated protein kinase C activity and potentiated the angiotensin II-induced inositol trisphosphate (InsP3) formation. This increased response to angiotensin II occurred without a significant change in the receptor number or Kd value of angiotensin II binding to the cells. The biologically inactive phorbol ester 4α-phorbol 12,13-di-decanoate was without effect on angiotensin II-stimulated InsP3 generation. Long-term pretreatment with TPA also increased the angiotensin II-induced mobilization of Ca2+ and the subsequent contraction of mesangial cells. © 1990.
引用
收藏
页码：307 / 311
页数：5
相关论文
共 31 条
1234