THE PENETRATION OF ORAL CIPROFLOXACIN INTO THE AQUEOUS-HUMOR, VITREOUS, AND SUBRETINAL FLUID OF HUMANS

被引：97

作者：

LESK, MR ^{[1
]}

AMMANN, H ^{[1
]}

MARCIL, G ^{[1
]}

VINET, B ^{[1
]}

LAMER, L ^{[1
]}

SEBAG, M ^{[1
]}

机构：

[1] NOTRE DAME HOSP, DEPT BIOCHEM, MONTREAL H2L 4M1, PQ, CANADA

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1993年 / 115卷 / 05期

关键词：

D O I：

10.1016/S0002-9394(14)71460-6

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We examined ciprofloxacin levels in the aqueous humor, vitreous, or subretinal fluid in 40 patients undergoing cataract extraction, vitrectomy, or scleral buckling. Ciprofloxacin, 750 mg, was administered orally an average of 17 1/2 and 5 1/2 hours preoperatively. We obtained mean ciprofloxacin levels of 0.53 mug/ml in aqueous humor, 0.51 mug/ml in vitreous, and 0.71 mug/ml in subretinal fluid. These vitreous levels exceed the minimum inhibitory concentration (MIC)90 of Staphylococcus epidermidis, Propionibacterium species, Pseudomonas aeruginosa, Proteus mirabilis, and Haemophilus influenzae, as well as the MIC70 of S. aureus and Bacillus cereus. Therefore, ciprofloxacin may have a role in the management and prevention of endophthalmitis.

引用

页码：623 / 628

页数：6

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